Distributed representation of visual objects by single neurons in the human brain

André B. Valdez, Megan H. Papesh, David M. Treiman, Kris A. Smith, Stephen Goldinger, Peter N. Steinmetz

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

It remains unclear how single neurons in the human brain represent whole-object visual stimuli. While recordings in both human and nonhuman primates have shown distributed representations of objects (many neurons encoding multiple objects), recordings of single neurons in the human medial temporal lobe, taken as subjects’ discriminated objects during multiple presentations, have shown gnostic representations (single neurons encoding one object). Because some studies suggest that repeated viewing may enhance neural selectivity for objects, we had human subjects discriminate objects in a single, more naturalistic viewing session. We found that, across 432 well isolated neurons recorded in the hippocampus and amygdala, the average fraction of objects encoded was 26%. We also found that more neurons encoded several objects versus only one object in the hippocampus (28 vs 18%, p < 0.001) and in the amygdala (30 vs 19%, p < 0.001). Thus, during realistic viewing experiences, typical neurons in the human medial temporal lobe code for a considerable range of objects, across multiple semantic categories.

Original languageEnglish (US)
Pages (from-to)5180-5186
Number of pages7
JournalJournal of Neuroscience
Volume35
Issue number13
DOIs
StatePublished - Apr 1 2015

Keywords

  • Distributed representation
  • Human single neuron
  • Medial temporal lobe
  • Object representation

ASJC Scopus subject areas

  • Neuroscience(all)

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    Valdez, A. B., Papesh, M. H., Treiman, D. M., Smith, K. A., Goldinger, S., & Steinmetz, P. N. (2015). Distributed representation of visual objects by single neurons in the human brain. Journal of Neuroscience, 35(13), 5180-5186. https://doi.org/10.1523/JNEUROSCI.1958-14.2015