Distinct patterns of brain activity in progressive supranuclear palsy and Parkinson’s disease

Roxana G. Burciu, Edward Ofori, Priyank Shukla, Peggy J. Planetta, Amy F. Snyder, Hong Li, Chris J. Hass, Michael S. Okun, Nikolaus R. McFarland, David E. Vaillancourt

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Background: The basal ganglia-thalamo-cortical and cerebello-thalamo-cortical circuits are important for motor control. Whether their functioning is affected in a similar or different way by progressive supranuclear palsy (PSP) and Parkinson’s disease (PD) is not clear. Methods: A functional magnetic resonance imaging (fMRI) force production paradigm and voxel-based morphometry were used to assess differences in brain activity and macrostructural volumes between PSP, PD, and healthy age-matched controls. Results: We found that PSP and PD share reduced functional activity of the basal ganglia and cortical motor areas, but this is more pronounced in PSP than in PD. In PSP the frontal regions are underactive, whereas the posterior parietal and occipital regions are overactive as compared with controls and PD. Furthermore, lobules I through IV, V, and VI of the cerebellum are hypoactive in PSP and PD, whereas Crus I and lobule IX are hyperactive in PSP only. Reductions in gray and white matter volume are specific to PSP. Finally, the functional status of the caudate as well as the volume of the superior frontal gyrus predict clinical gait and posture measures in PSP. Conclusions: PSP and PD share hypoactivity of the basal ganglia, motor cortex, and anterior cerebellum. These patients also display a unique pattern, such that anterior regions of the cortex are hypoactive and posterior regions of the cortex and cerebellum are hyperactive. Together, these findings suggest that specific structures within the basal ganglia, cortex, and cerebellum are affected differently in PSP relative to PD.

Original languageEnglish (US)
Pages (from-to)1248-1258
Number of pages11
JournalMovement Disorders
Volume30
Issue number9
DOIs
StatePublished - Aug 1 2015
Externally publishedYes

Fingerprint

Progressive Supranuclear Palsy
Parkinson Disease
Brain
Basal Ganglia
Cerebellum
Motor Cortex
Occipital Lobe
Parietal Lobe
Prefrontal Cortex
Posture
Gait
Magnetic Resonance Imaging

Keywords

  • Force
  • Functional MRI
  • Motor circuits
  • Parkinson’s disease
  • Progressive supranuclear palsy

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this

Burciu, R. G., Ofori, E., Shukla, P., Planetta, P. J., Snyder, A. F., Li, H., ... Vaillancourt, D. E. (2015). Distinct patterns of brain activity in progressive supranuclear palsy and Parkinson’s disease. Movement Disorders, 30(9), 1248-1258. https://doi.org/10.1002/mds.26294

Distinct patterns of brain activity in progressive supranuclear palsy and Parkinson’s disease. / Burciu, Roxana G.; Ofori, Edward; Shukla, Priyank; Planetta, Peggy J.; Snyder, Amy F.; Li, Hong; Hass, Chris J.; Okun, Michael S.; McFarland, Nikolaus R.; Vaillancourt, David E.

In: Movement Disorders, Vol. 30, No. 9, 01.08.2015, p. 1248-1258.

Research output: Contribution to journalArticle

Burciu, RG, Ofori, E, Shukla, P, Planetta, PJ, Snyder, AF, Li, H, Hass, CJ, Okun, MS, McFarland, NR & Vaillancourt, DE 2015, 'Distinct patterns of brain activity in progressive supranuclear palsy and Parkinson’s disease', Movement Disorders, vol. 30, no. 9, pp. 1248-1258. https://doi.org/10.1002/mds.26294
Burciu, Roxana G. ; Ofori, Edward ; Shukla, Priyank ; Planetta, Peggy J. ; Snyder, Amy F. ; Li, Hong ; Hass, Chris J. ; Okun, Michael S. ; McFarland, Nikolaus R. ; Vaillancourt, David E. / Distinct patterns of brain activity in progressive supranuclear palsy and Parkinson’s disease. In: Movement Disorders. 2015 ; Vol. 30, No. 9. pp. 1248-1258.
@article{444cfc13b7ed4e77be6db328815c32bd,
title = "Distinct patterns of brain activity in progressive supranuclear palsy and Parkinson’s disease",
abstract = "Background: The basal ganglia-thalamo-cortical and cerebello-thalamo-cortical circuits are important for motor control. Whether their functioning is affected in a similar or different way by progressive supranuclear palsy (PSP) and Parkinson’s disease (PD) is not clear. Methods: A functional magnetic resonance imaging (fMRI) force production paradigm and voxel-based morphometry were used to assess differences in brain activity and macrostructural volumes between PSP, PD, and healthy age-matched controls. Results: We found that PSP and PD share reduced functional activity of the basal ganglia and cortical motor areas, but this is more pronounced in PSP than in PD. In PSP the frontal regions are underactive, whereas the posterior parietal and occipital regions are overactive as compared with controls and PD. Furthermore, lobules I through IV, V, and VI of the cerebellum are hypoactive in PSP and PD, whereas Crus I and lobule IX are hyperactive in PSP only. Reductions in gray and white matter volume are specific to PSP. Finally, the functional status of the caudate as well as the volume of the superior frontal gyrus predict clinical gait and posture measures in PSP. Conclusions: PSP and PD share hypoactivity of the basal ganglia, motor cortex, and anterior cerebellum. These patients also display a unique pattern, such that anterior regions of the cortex are hypoactive and posterior regions of the cortex and cerebellum are hyperactive. Together, these findings suggest that specific structures within the basal ganglia, cortex, and cerebellum are affected differently in PSP relative to PD.",
keywords = "Force, Functional MRI, Motor circuits, Parkinson’s disease, Progressive supranuclear palsy",
author = "Burciu, {Roxana G.} and Edward Ofori and Priyank Shukla and Planetta, {Peggy J.} and Snyder, {Amy F.} and Hong Li and Hass, {Chris J.} and Okun, {Michael S.} and McFarland, {Nikolaus R.} and Vaillancourt, {David E.}",
year = "2015",
month = "8",
day = "1",
doi = "10.1002/mds.26294",
language = "English (US)",
volume = "30",
pages = "1248--1258",
journal = "Movement Disorders",
issn = "0885-3185",
publisher = "John Wiley and Sons Inc.",
number = "9",

}

TY - JOUR

T1 - Distinct patterns of brain activity in progressive supranuclear palsy and Parkinson’s disease

AU - Burciu, Roxana G.

AU - Ofori, Edward

AU - Shukla, Priyank

AU - Planetta, Peggy J.

AU - Snyder, Amy F.

AU - Li, Hong

AU - Hass, Chris J.

AU - Okun, Michael S.

AU - McFarland, Nikolaus R.

AU - Vaillancourt, David E.

PY - 2015/8/1

Y1 - 2015/8/1

N2 - Background: The basal ganglia-thalamo-cortical and cerebello-thalamo-cortical circuits are important for motor control. Whether their functioning is affected in a similar or different way by progressive supranuclear palsy (PSP) and Parkinson’s disease (PD) is not clear. Methods: A functional magnetic resonance imaging (fMRI) force production paradigm and voxel-based morphometry were used to assess differences in brain activity and macrostructural volumes between PSP, PD, and healthy age-matched controls. Results: We found that PSP and PD share reduced functional activity of the basal ganglia and cortical motor areas, but this is more pronounced in PSP than in PD. In PSP the frontal regions are underactive, whereas the posterior parietal and occipital regions are overactive as compared with controls and PD. Furthermore, lobules I through IV, V, and VI of the cerebellum are hypoactive in PSP and PD, whereas Crus I and lobule IX are hyperactive in PSP only. Reductions in gray and white matter volume are specific to PSP. Finally, the functional status of the caudate as well as the volume of the superior frontal gyrus predict clinical gait and posture measures in PSP. Conclusions: PSP and PD share hypoactivity of the basal ganglia, motor cortex, and anterior cerebellum. These patients also display a unique pattern, such that anterior regions of the cortex are hypoactive and posterior regions of the cortex and cerebellum are hyperactive. Together, these findings suggest that specific structures within the basal ganglia, cortex, and cerebellum are affected differently in PSP relative to PD.

AB - Background: The basal ganglia-thalamo-cortical and cerebello-thalamo-cortical circuits are important for motor control. Whether their functioning is affected in a similar or different way by progressive supranuclear palsy (PSP) and Parkinson’s disease (PD) is not clear. Methods: A functional magnetic resonance imaging (fMRI) force production paradigm and voxel-based morphometry were used to assess differences in brain activity and macrostructural volumes between PSP, PD, and healthy age-matched controls. Results: We found that PSP and PD share reduced functional activity of the basal ganglia and cortical motor areas, but this is more pronounced in PSP than in PD. In PSP the frontal regions are underactive, whereas the posterior parietal and occipital regions are overactive as compared with controls and PD. Furthermore, lobules I through IV, V, and VI of the cerebellum are hypoactive in PSP and PD, whereas Crus I and lobule IX are hyperactive in PSP only. Reductions in gray and white matter volume are specific to PSP. Finally, the functional status of the caudate as well as the volume of the superior frontal gyrus predict clinical gait and posture measures in PSP. Conclusions: PSP and PD share hypoactivity of the basal ganglia, motor cortex, and anterior cerebellum. These patients also display a unique pattern, such that anterior regions of the cortex are hypoactive and posterior regions of the cortex and cerebellum are hyperactive. Together, these findings suggest that specific structures within the basal ganglia, cortex, and cerebellum are affected differently in PSP relative to PD.

KW - Force

KW - Functional MRI

KW - Motor circuits

KW - Parkinson’s disease

KW - Progressive supranuclear palsy

UR - http://www.scopus.com/inward/record.url?scp=84935429640&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84935429640&partnerID=8YFLogxK

U2 - 10.1002/mds.26294

DO - 10.1002/mds.26294

M3 - Article

C2 - 26148135

AN - SCOPUS:84935429640

VL - 30

SP - 1248

EP - 1258

JO - Movement Disorders

JF - Movement Disorders

SN - 0885-3185

IS - 9

ER -