Abstract
Emerging evidence implicates the midbrain dopamine system and its interactions with the lateral habenula in processing aversive information and learning to avoid negative outcomes. We examined neural responses to unexpected, aversive events using methods specialized for imaging the midbrain and habenula in humans. Robust activation to aversive relative to neutral events was observed in the habenula and two regions within the ventral midbrain: one located within the ventral tegmental area (VTA) and the other in the substantia nigra (SN). Aversive processing increased functional connectivity between the VTA and the habenula, putamen, and medial prefrontal cortex, whereas the SN exhibited a different pattern of functional connectivity. Our findings provide evidence for a network comprising the VTA and SN, the habenula, and mesocorticolimbic structures that supports processing aversive events in humans.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 198-208 |
| Number of pages | 11 |
| Journal | Journal of Neuroscience |
| Volume | 35 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 7 2015 |
| Externally published | Yes |
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Keywords
- Aversion
- Avoidance
- Dopamine
- fMRI
- Midbrain
- Ventral tegmental area
ASJC Scopus subject areas
- Neuroscience(all)
Cite this
Distinct midbrain and habenula pathways are involved in processing aversive events in humans. / Hennigan, Kelly; McClure, Kimberlee; McClure, Samuel.
In: Journal of Neuroscience, Vol. 35, No. 1, 07.01.2015, p. 198-208.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Distinct midbrain and habenula pathways are involved in processing aversive events in humans
AU - Hennigan, Kelly
AU - McClure, Kimberlee
AU - McClure, Samuel
PY - 2015/1/7
Y1 - 2015/1/7
N2 - Emerging evidence implicates the midbrain dopamine system and its interactions with the lateral habenula in processing aversive information and learning to avoid negative outcomes. We examined neural responses to unexpected, aversive events using methods specialized for imaging the midbrain and habenula in humans. Robust activation to aversive relative to neutral events was observed in the habenula and two regions within the ventral midbrain: one located within the ventral tegmental area (VTA) and the other in the substantia nigra (SN). Aversive processing increased functional connectivity between the VTA and the habenula, putamen, and medial prefrontal cortex, whereas the SN exhibited a different pattern of functional connectivity. Our findings provide evidence for a network comprising the VTA and SN, the habenula, and mesocorticolimbic structures that supports processing aversive events in humans.
AB - Emerging evidence implicates the midbrain dopamine system and its interactions with the lateral habenula in processing aversive information and learning to avoid negative outcomes. We examined neural responses to unexpected, aversive events using methods specialized for imaging the midbrain and habenula in humans. Robust activation to aversive relative to neutral events was observed in the habenula and two regions within the ventral midbrain: one located within the ventral tegmental area (VTA) and the other in the substantia nigra (SN). Aversive processing increased functional connectivity between the VTA and the habenula, putamen, and medial prefrontal cortex, whereas the SN exhibited a different pattern of functional connectivity. Our findings provide evidence for a network comprising the VTA and SN, the habenula, and mesocorticolimbic structures that supports processing aversive events in humans.
KW - Aversion
KW - Avoidance
KW - Dopamine
KW - fMRI
KW - Midbrain
KW - Ventral tegmental area
UR - http://www.scopus.com/inward/record.url?scp=84920528631&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84920528631&partnerID=8YFLogxK
U2 - 10.1523/JNEUROSCI.0927-14.2015
DO - 10.1523/JNEUROSCI.0927-14.2015
M3 - Article
C2 - 25568114
AN - SCOPUS:84920528631
VL - 35
SP - 198
EP - 208
JO - Journal of Neuroscience
JF - Journal of Neuroscience
SN - 0270-6474
IS - 1
ER -