Disrupted sleep is associated with altered pain processing by sex and ethnicity in knee osteoarthritis

Megan Petrov, Burel R. Goodin, Yenisel Cruz-Almeida, Chris King, Toni L. Glover, Hailey W. Bulls, Matthew Herbert, Kimberly T. Sibille, Emily J. Bartley, Barri J. Fessler, Adriana Sotolongo, Roland Staud, David Redden, Roger B. Fillingim, Laurence A. Bradley

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

Studies indicate that improving sleep decreases reported pain in patients with knee osteoarthritis, but it is unclear if this association extends to experimentally induced pain responses. A community-based sample of 88 African American and 52 non-Hispanic white adults (45-76 years) with knee osteoarthritis completed the Insomnia Severity Index and the arousal subscale of the Sleep Hygiene and Practices Scale. Participants underwent quantitative sensory testing, including measures of pain sensitivity and facilitation at the knee, and pain inhibition. Outcomes were analyzed with multiple Tobit hierarchical regression models, with adjustment for relevant covariates. Ethnicity and sex by sleep interactions were also entered into the models. After covariate adjustment, main associations were not observed. However, sex interacted with insomnia severity to predict greater temporal summation of heat and punctate pressure pain among women and lower heat temporal summation among men. Men and women who engaged in frequent arousal-associated sleep behaviors demonstrated higher and lower heat temporal summation, respectively. Non-Hispanic whites with greater insomnia severity displayed lower pressure pain thresholds and pain inhibition. Our findings are the first to demonstrate that disrupted sleep is associated with altered pain processing differentially by sex and ethnicity/race among people with knee osteoarthritis. Perspective This article presents the association between insomnia severity, maladaptive sleep behaviors, and experimentally induced pain responses among people with knee osteoarthritis. Disrupted sleep was associated with altered pain processing by sex and ethnicity/race. Offering sleep interventions may help ameliorate pain, but treatment may need to be tailored by sex and ethnicity/race.

Original languageEnglish (US)
Pages (from-to)478-490
Number of pages13
JournalJournal of Pain
Volume16
Issue number5
DOIs
Publication statusPublished - May 1 2015

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Keywords

  • Quantitative sensory testing knee osteoarthritis insomnia sleep ethnicity

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine
  • Neurology
  • Clinical Neurology

Cite this

Petrov, M., Goodin, B. R., Cruz-Almeida, Y., King, C., Glover, T. L., Bulls, H. W., ... Bradley, L. A. (2015). Disrupted sleep is associated with altered pain processing by sex and ethnicity in knee osteoarthritis. Journal of Pain, 16(5), 478-490. https://doi.org/10.1016/j.jpain.2015.02.004