TY - JOUR
T1 - Dispersal evolution in neoplasms
T2 - The role of disregulated metabolism in the evolution of cell motility
AU - Aktipis, C Athena
AU - Maley, Carlo
AU - Pepper, John W.
PY - 2012/2
Y1 - 2012/2
N2 - Here, we apply the theoretical framework of dispersal evolution to understand the emergence of invasive and metastatic cells. We investigate whether the dysregulated metabolism characteristic of cancer cells may play a causal role in selection for cell motility, and thus to the tissue invasion and metastasis that define cancer. With an agent-based computational model, we show that cells with higher metabolism evolve to have higher rates of movement and that "neoplastic" cells with higher metabolism rates are able to persist in a population of "normal" cells with low metabolic rates, but only if increased metabolism is accompanied by increased motility. This is true even when the cost of motility is high. These findings suggest that higher rates of cell metabolism lead to selection for motile cells in premalignant neoplasms, which may preadapt cells for subsequent invasion and metastasis. This has important implications for understanding the progression of cancer from less invasive to more invasive cell types.
AB - Here, we apply the theoretical framework of dispersal evolution to understand the emergence of invasive and metastatic cells. We investigate whether the dysregulated metabolism characteristic of cancer cells may play a causal role in selection for cell motility, and thus to the tissue invasion and metastasis that define cancer. With an agent-based computational model, we show that cells with higher metabolism evolve to have higher rates of movement and that "neoplastic" cells with higher metabolism rates are able to persist in a population of "normal" cells with low metabolic rates, but only if increased metabolism is accompanied by increased motility. This is true even when the cost of motility is high. These findings suggest that higher rates of cell metabolism lead to selection for motile cells in premalignant neoplasms, which may preadapt cells for subsequent invasion and metastasis. This has important implications for understanding the progression of cancer from less invasive to more invasive cell types.
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U2 - 10.1158/1940-6207.CAPR-11-0004
DO - 10.1158/1940-6207.CAPR-11-0004
M3 - Article
C2 - 21930797
AN - SCOPUS:84857677326
SN - 1940-6207
VL - 5
SP - 266
EP - 275
JO - Cancer Prevention Research
JF - Cancer Prevention Research
IS - 2
ER -