Disease Modification for Parkinson's Disease: Axonal Regeneration and Trophic Factors

Jeffrey H. Kordower, Robert E. Burke

Research output: Contribution to journalReview articlepeer-review

16 Scopus citations

Abstract

Disease modification and structural neuroprotection have been the holy grail for Parkinson's disease (PD) experimental therapeutics. Theoretically, there are a number of ways to implement such therapeutics, but to date all have failed. This review examines the potential of axonal regeneration and trophic factor delivery for the nigrostriatal system as 2 such approaches that historically have initiated much excitement. However, we conclude this discussion with the following question: has science passed these approaches by?

Original languageEnglish (US)
Pages (from-to)678-683
Number of pages6
JournalMovement Disorders
Volume33
Issue number5
DOIs
StatePublished - May 2018
Externally publishedYes

Keywords

  • axons
  • Disease modification
  • Trophic Factors

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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