Disease Modification for Parkinson's Disease: Axonal Regeneration and Trophic Factors

Jeffrey H. Kordower; Robert E. Burke

doi:10.1002/mds.27383

Disease Modification for Parkinson's Disease: Axonal Regeneration and Trophic Factors

Jeffrey H. Kordower, Robert E. Burke

Research output: Contribution to journal › Review article › peer-review

24 Scopus citations

Abstract

Disease modification and structural neuroprotection have been the holy grail for Parkinson's disease (PD) experimental therapeutics. Theoretically, there are a number of ways to implement such therapeutics, but to date all have failed. This review examines the potential of axonal regeneration and trophic factor delivery for the nigrostriatal system as 2 such approaches that historically have initiated much excitement.

Original language	English (US)
Pages (from-to)	678-683
Number of pages	6
Journal	Movement Disorders
Volume	33
Issue number	5
DOIs	https://doi.org/10.1002/mds.27383
State	Published - May 2018
Externally published	Yes

Keywords

Disease modification
Trophic Factors
axons

ASJC Scopus subject areas

Neurology
Clinical Neurology

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10.1002/mds.27383

Cite this

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title = "Disease Modification for Parkinson's Disease: Axonal Regeneration and Trophic Factors",

abstract = "Disease modification and structural neuroprotection have been the holy grail for Parkinson's disease (PD) experimental therapeutics. Theoretically, there are a number of ways to implement such therapeutics, but to date all have failed. This review examines the potential of axonal regeneration and trophic factor delivery for the nigrostriatal system as 2 such approaches that historically have initiated much excitement.",

keywords = "Disease modification, Trophic Factors, axons",

author = "Kordower, {Jeffrey H.} and Burke, {Robert E.}",

note = "Funding Information: JHK is supported in part by a center grant from the Parkinson's Disease Foundation. Funding Information: Acknowledgment: JHK is supported in part by a center grant from the Parkinson{\textquoteright}s Disease Foundation. Publisher Copyright: {\textcopyright} 2018 International Parkinson and Movement Disorder Society",

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AU - Burke, Robert E.

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PY - 2018/5

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N2 - Disease modification and structural neuroprotection have been the holy grail for Parkinson's disease (PD) experimental therapeutics. Theoretically, there are a number of ways to implement such therapeutics, but to date all have failed. This review examines the potential of axonal regeneration and trophic factor delivery for the nigrostriatal system as 2 such approaches that historically have initiated much excitement.

AB - Disease modification and structural neuroprotection have been the holy grail for Parkinson's disease (PD) experimental therapeutics. Theoretically, there are a number of ways to implement such therapeutics, but to date all have failed. This review examines the potential of axonal regeneration and trophic factor delivery for the nigrostriatal system as 2 such approaches that historically have initiated much excitement.

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Disease Modification for Parkinson's Disease: Axonal Regeneration and Trophic Factors

Abstract

Keywords

ASJC Scopus subject areas

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