Discrimination between Obesity and Insulin Resistance in the Relationship with Adiponectin

Fahim Abbasi, James W. Chu, Cindy Lamendola, Tracey McLaughlin, John Hayden, Gerald M. Reaven, Peter D. Reaven

Research output: Contribution to journalArticle

210 Citations (Scopus)

Abstract

Insulin resistance and obesity are both associated with lower plasma adiponectin concentrations. Since insulin resistance and obesity are related, the extent to which the association of adiponectin with insulin resistance is dependent on its relationship with obesity is unclear. To address this issue, fasting plasma adiponectin concentrations were measured in 60 nondiabetic subjects, stratified into four equal groups on the basis of both their degree of adiposity and insulin resistance. Insulin resistance was quantified by determining the steady-state plasma glucose (SSPG) concentration in response to an infusion of octreotide, glucose, and insulin, and degree of adiposity was assessed by BMI. Subjects were defined as obese (BMI ≥ 30.0 kg/m 2) or nonobese (< 27.0 kg/m2) and as either insulin sensitive (SSPG < 100 mg/dl) or insulin resistant (> 190 mg/dl). Insulin-resistant subjects had significantly (P < 0.001) lower (mean ± SD) adiponectin concentrations, whether they were obese (17.1 ± 5.9 μg/ml) or nonobese (16.3 ± 7.5 μg/ml) as compared with either obese, insulin-sensitive (34.3 ± 13.1 μg/ml) or nonobese, insulin-sensitive (29.8 ± 15.3 μ/ml) subjects. Finally, adiponectin levels in insulin-sensitive subjects varied to a significantly greater degree than in insulin-resistant subjects. These results suggest that adiponectin concentrations are more closely related to differences in insulin-mediated glucose disposal than obesity.

Original languageEnglish (US)
Pages (from-to)585-590
Number of pages6
JournalDiabetes
Volume53
Issue number3
DOIs
StatePublished - Mar 1 2004
Externally publishedYes

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Adiponectin
Insulin Resistance
Obesity
Insulin
Adiposity
Glucose
Octreotide
Fasting

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

Cite this

Abbasi, F., Chu, J. W., Lamendola, C., McLaughlin, T., Hayden, J., Reaven, G. M., & Reaven, P. D. (2004). Discrimination between Obesity and Insulin Resistance in the Relationship with Adiponectin. Diabetes, 53(3), 585-590. https://doi.org/10.2337/diabetes.53.3.585

Discrimination between Obesity and Insulin Resistance in the Relationship with Adiponectin. / Abbasi, Fahim; Chu, James W.; Lamendola, Cindy; McLaughlin, Tracey; Hayden, John; Reaven, Gerald M.; Reaven, Peter D.

In: Diabetes, Vol. 53, No. 3, 01.03.2004, p. 585-590.

Research output: Contribution to journalArticle

Abbasi, F, Chu, JW, Lamendola, C, McLaughlin, T, Hayden, J, Reaven, GM & Reaven, PD 2004, 'Discrimination between Obesity and Insulin Resistance in the Relationship with Adiponectin', Diabetes, vol. 53, no. 3, pp. 585-590. https://doi.org/10.2337/diabetes.53.3.585
Abbasi F, Chu JW, Lamendola C, McLaughlin T, Hayden J, Reaven GM et al. Discrimination between Obesity and Insulin Resistance in the Relationship with Adiponectin. Diabetes. 2004 Mar 1;53(3):585-590. https://doi.org/10.2337/diabetes.53.3.585
Abbasi, Fahim ; Chu, James W. ; Lamendola, Cindy ; McLaughlin, Tracey ; Hayden, John ; Reaven, Gerald M. ; Reaven, Peter D. / Discrimination between Obesity and Insulin Resistance in the Relationship with Adiponectin. In: Diabetes. 2004 ; Vol. 53, No. 3. pp. 585-590.
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