TY - JOUR
T1 - Discovery of novel fish papillomaviruses
T2 - From the Antarctic to the commercial fish market
AU - Kraberger, Simona
AU - Austin, Charlotte
AU - Farkas, Kata
AU - Desvignes, Thomas
AU - Postlethwait, John H.
AU - Fontenele, Rafaela S.
AU - Schmidlin, Kara
AU - Bradley, Russell W.
AU - Warzybok, Pete
AU - Van Doorslaer, Koenraad
AU - Davison, William
AU - Buck, Christopher B.
AU - Varsani, Arvind
N1 - Publisher Copyright:
© 2021 Elsevier Inc.
PY - 2022/1/2
Y1 - 2022/1/2
N2 - Fish papillomaviruses form a newly discovered group broadly recognized as the Secondpapillomavirinae subfamily. This study expands the documented genomes of the fish papillomaviruses from six to 16, including one from the Antarctic emerald notothen, seven from commercial market fishes, one from data mining of sea bream sequence data, and one from a western gull cloacal swab that is likely diet derived. The genomes of secondpapillomaviruses are ∼6 kilobasepairs (kb), which is substantially smaller than the ∼8 kb of terrestrial vertebrate papillomaviruses. Each genome encodes a clear homolog of the four canonical papillomavirus genes, E1, E2, L1, and L2. In addition, we identified open reading frames (ORFs) with short linear peptide motifs reminiscent of E6/E7 oncoproteins. Fish papillomaviruses are extremely diverse and phylogenetically distant from other papillomaviruses suggesting a model in which terrestrial vertebrate-infecting papillomaviruses arose after an evolutionary bottleneck event, possibly during the water-to-land transition.
AB - Fish papillomaviruses form a newly discovered group broadly recognized as the Secondpapillomavirinae subfamily. This study expands the documented genomes of the fish papillomaviruses from six to 16, including one from the Antarctic emerald notothen, seven from commercial market fishes, one from data mining of sea bream sequence data, and one from a western gull cloacal swab that is likely diet derived. The genomes of secondpapillomaviruses are ∼6 kilobasepairs (kb), which is substantially smaller than the ∼8 kb of terrestrial vertebrate papillomaviruses. Each genome encodes a clear homolog of the four canonical papillomavirus genes, E1, E2, L1, and L2. In addition, we identified open reading frames (ORFs) with short linear peptide motifs reminiscent of E6/E7 oncoproteins. Fish papillomaviruses are extremely diverse and phylogenetically distant from other papillomaviruses suggesting a model in which terrestrial vertebrate-infecting papillomaviruses arose after an evolutionary bottleneck event, possibly during the water-to-land transition.
KW - Centropristis striata
KW - Larus occidentalis
KW - Melanogrammus aeglefinus
KW - Papillomavirus
KW - Sparus aurata
KW - Trematomus bernacchii
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UR - http://www.scopus.com/inward/citedby.url?scp=85118511929&partnerID=8YFLogxK
U2 - 10.1016/j.virol.2021.10.007
DO - 10.1016/j.virol.2021.10.007
M3 - Article
C2 - 34739918
AN - SCOPUS:85118511929
SN - 0042-6822
VL - 565
SP - 65
EP - 72
JO - Virology
JF - Virology
ER -