Discovery and development of biomarkers of neurological disease

Travis Dunckley, Keith D. Coon, Dietrich A. Stephan

Research output: Contribution to journalReview article

58 Scopus citations

Abstract

The identification of clinically relevant biomarkers for neurological diseases poses unique challenges. These include an historical lack of availability of relevant tissues from the site of pathology, relatively poorly matured techniques for disease diagnosis, the complexity and cellular heterogeneity of the brain, and a clear deficiency of models for functional validation of candidate biomarkers. Here, the unique challenges that neurological disorders introduce to biomarker discovery are described and how modern technological advances in genomics, proteomics and metabolomics are overcoming these obstacles and are driving the discovery of novel biomarkers to improve early diagnosis and therapeutic treatment is discussed.

Original languageEnglish (US)
Pages (from-to)326-334
Number of pages9
JournalDrug discovery today
Volume10
Issue number5
DOIs
StatePublished - Mar 1 2005
Externally publishedYes

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

Fingerprint Dive into the research topics of 'Discovery and development of biomarkers of neurological disease'. Together they form a unique fingerprint.

  • Cite this