Direct analysis of micro area on tooth surface by surface desorption atmospheric pressure chemical ionization mass spectrometry

Jiang Wang, Qian Li, Haiwei Gu, Xiaotun Guo, Shuiping Yang, Zhihao Wang

Research output: Contribution to journalArticle

1 Scopus citations


A novel analytical platform based on a nanoliter needle for sampling and surface desorption atmospheric pressure chemistry ionization mass spectrometry(SDAPCI-MS) for analysis was developed for the direct, fast and micro-area analysis of different parts of a human tooth, including cavity, cavity edge, tooth cusp and tooth sulcus. The results showed that the mass spectra from the four sampling spots on the same tooth were different, and that SDAPCI-MS detected lactic acid, pyruvic acid, phenylacetic acid and propanoic acid were confirmed using tandem mass spectrometry(MS/MS). Principal component analysis(PCA) of the mass spectral data successfully differentiated the different sampling spots, levels of tooth decay and levels of gum disease. Therefore, our nano-SDAPCI-MS approach provides a promising way for micro-area analysis with fast, minimal pretreatment sampling, enabling rapid, simple and reliable surface MS investigation.

Original languageEnglish (US)
Pages (from-to)1067-1073
Number of pages7
JournalGaodeng Xuexiao Huaxue Xuebao/Chemical Journal of Chinese Universities
Issue number6
StatePublished - Jan 1 2015
Externally publishedYes



  • Mass spectrometry
  • Micro-analysis
  • Surface desorption atmospheric pressure chemistry ionization
  • Tooth disease

ASJC Scopus subject areas

  • Chemistry(all)

Cite this