Differentiation of obsessive-compulsive-, panic-, obsessive-compulsive personality-, and non-disordered individuals by variation in the promoter region of the serotonin transporter gene

Marisol Perez La Mar, Jessica S. Brown, Suzanne Vrshek-Schallhorn, Frank Johnson, Thomas E. Joiner

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Past research investigating the role of the serotonin transporter gene in OCD has produced mixed findings. One possible reason for the mixed findings is comorbidity. In this study, non-comorbid OCD individuals were compared to non-disordered controls. A sample of panic disordered individuals was also compared to a non-disordered group. Finally, as an exploratory analysis, individuals were assessed for OCPD and their allelic frequencies were also compared to non-disordered individuals. Analyses revealed that there were higher frequencies of the s/s genotype among the OCD group when compared to non-disordered controls. There were no differences in allelic frequencies on the serotonin transporter gene between the panic disordered group, the OCPD group, and the non-disordered control group. This study found that non-comorbid OCD individuals tended to have a higher percentage of the homozygous short genotype than non-disordered individuals. The s/s genotype might serve as a contributory risk factor for OCD.

Original languageEnglish (US)
Pages (from-to)794-806
Number of pages13
JournalJournal of Anxiety Disorders
Volume20
Issue number6
DOIs
StatePublished - 2006
Externally publishedYes

Fingerprint

Compulsive Personality Disorder
Serotonin Plasma Membrane Transport Proteins
Panic
Genetic Promoter Regions
Genotype
Genes
Comorbidity
Control Groups
Research

Keywords

  • 5-HTTLPR
  • Obsessive-compulsive disorder
  • Obsessive-compulsive personality disorder
  • Panic disorder
  • Serotonin transporter gene

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Clinical Psychology

Cite this

Differentiation of obsessive-compulsive-, panic-, obsessive-compulsive personality-, and non-disordered individuals by variation in the promoter region of the serotonin transporter gene. / Perez La Mar, Marisol; Brown, Jessica S.; Vrshek-Schallhorn, Suzanne; Johnson, Frank; Joiner, Thomas E.

In: Journal of Anxiety Disorders, Vol. 20, No. 6, 2006, p. 794-806.

Research output: Contribution to journalArticle

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