TY - JOUR
T1 - Differentiation of obsessive-compulsive-, panic-, obsessive-compulsive personality-, and non-disordered individuals by variation in the promoter region of the serotonin transporter gene
AU - Perez, Marisol
AU - Brown, Jessica S.
AU - Vrshek-Schallhorn, Suzanne
AU - Johnson, Frank
AU - Joiner, Thomas E.
N1 - Funding Information:
This study was funded by the Obsessive-Compulsive Foundation.
Copyright:
Copyright 2011 Elsevier B.V., All rights reserved.
PY - 2006
Y1 - 2006
N2 - Past research investigating the role of the serotonin transporter gene in OCD has produced mixed findings. One possible reason for the mixed findings is comorbidity. In this study, non-comorbid OCD individuals were compared to non-disordered controls. A sample of panic disordered individuals was also compared to a non-disordered group. Finally, as an exploratory analysis, individuals were assessed for OCPD and their allelic frequencies were also compared to non-disordered individuals. Analyses revealed that there were higher frequencies of the s/s genotype among the OCD group when compared to non-disordered controls. There were no differences in allelic frequencies on the serotonin transporter gene between the panic disordered group, the OCPD group, and the non-disordered control group. This study found that non-comorbid OCD individuals tended to have a higher percentage of the homozygous short genotype than non-disordered individuals. The s/s genotype might serve as a contributory risk factor for OCD.
AB - Past research investigating the role of the serotonin transporter gene in OCD has produced mixed findings. One possible reason for the mixed findings is comorbidity. In this study, non-comorbid OCD individuals were compared to non-disordered controls. A sample of panic disordered individuals was also compared to a non-disordered group. Finally, as an exploratory analysis, individuals were assessed for OCPD and their allelic frequencies were also compared to non-disordered individuals. Analyses revealed that there were higher frequencies of the s/s genotype among the OCD group when compared to non-disordered controls. There were no differences in allelic frequencies on the serotonin transporter gene between the panic disordered group, the OCPD group, and the non-disordered control group. This study found that non-comorbid OCD individuals tended to have a higher percentage of the homozygous short genotype than non-disordered individuals. The s/s genotype might serve as a contributory risk factor for OCD.
KW - 5-HTTLPR
KW - Obsessive-compulsive disorder
KW - Obsessive-compulsive personality disorder
KW - Panic disorder
KW - Serotonin transporter gene
UR - http://www.scopus.com/inward/record.url?scp=33745973652&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33745973652&partnerID=8YFLogxK
U2 - 10.1016/j.janxdis.2005.09.001
DO - 10.1016/j.janxdis.2005.09.001
M3 - Article
C2 - 16303282
AN - SCOPUS:33745973652
SN - 0887-6185
VL - 20
SP - 794
EP - 806
JO - Journal of Anxiety Disorders
JF - Journal of Anxiety Disorders
IS - 6
ER -