Differentiating the biomechanics of normal and diseased cells using isotropically etched silicon microstructures and atomic force microscopy

Mehdi Nikkhah, Jeannine S. Strobl, Masoud Agah

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

This paper reports studying the differential biomechanical properties of HS68 normal human fibroblast cells and MDA-MB-231 human breast cancer cell (as the key cell types in tumour microenvironment [1]) using MEMS-based three dimensional (3-D) silicon microstructures and Atomic Force Microscopy (AFM). AFM results indicates that the cancer cells have significantly softer cytoskeletal structure (E=0.51±0.35 kPa) compared to normal fibroblast cells (E=1.86±1.13 kPa) supporting our previous observations and explaining the differential adhesion of normal and diseased cells to different compartments of the 3-D silicon microstructures.

Original languageEnglish (US)
Title of host publicationProceedings of Conference, MicroTAS 2009 - The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences
PublisherChemical and Biological Microsystems Society
Pages1805-1807
Number of pages3
ISBN (Print)9780979806421
StatePublished - 2009
Externally publishedYes
Event13th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2009 - Jeju, Korea, Republic of
Duration: Nov 1 2009Nov 5 2009

Publication series

NameProceedings of Conference, MicroTAS 2009 - The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences

Other

Other13th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2009
Country/TerritoryKorea, Republic of
CityJeju
Period11/1/0911/5/09

Keywords

  • AFM
  • Breast cancer
  • Isotropic microchambers
  • MEMS
  • Silicon

ASJC Scopus subject areas

  • Chemical Engineering (miscellaneous)
  • Bioengineering

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