Abstract
A dextran hydrogel was synthesized from cross-linking a blend of acryloylated dextran and dextran bioconjugate. The conjugated dextran contains matrix metalloproteinase (MMP) sensitive peptides forming crosslinks that promotes cell-induced enzymatic degradation of the hydrogel and migration through the gel. By changing the ratio of cleavable cross-links to stable cross-links in the hydrogel, the extent of cell invasion into the gel (tissue ingrowth) can be regulated. At twenty-four hours, the extent of migration ranged from 0.25 to 13.6% area covered by cells based on the level of degradable crosslinks within the gel. It was discovered that the gel proportion containing 80% acryloylated dextran and 20% conjugated dextran limited the most cell migration.
Original language | English (US) |
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Title of host publication | Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings |
Editors | R.S. Leder |
Pages | 1203-1206 |
Number of pages | 4 |
Volume | 2 |
State | Published - 2003 |
Event | A New Beginning for Human Health: Proceddings of the 25th Annual International Conference of the IEEE Engineering in Medicine and Biology Society - Cancun, Mexico Duration: Sep 17 2003 → Sep 21 2003 |
Other
Other | A New Beginning for Human Health: Proceddings of the 25th Annual International Conference of the IEEE Engineering in Medicine and Biology Society |
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Country | Mexico |
City | Cancun |
Period | 9/17/03 → 9/21/03 |
Keywords
- Cell migration
- Dextran
ASJC Scopus subject areas
- Bioengineering