Dextran-Based Hydrogel to Regulate Tissue Growth

D. C. Hom, Chad E. Kennedy, G. Ehteshami, Stephen Massia

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

A dextran hydrogel was synthesized from cross-linking a blend of acryloylated dextran and dextran bioconjugate. The conjugated dextran contains matrix metalloproteinase (MMP) sensitive peptides forming crosslinks that promotes cell-induced enzymatic degradation of the hydrogel and migration through the gel. By changing the ratio of cleavable cross-links to stable cross-links in the hydrogel, the extent of cell invasion into the gel (tissue ingrowth) can be regulated. At twenty-four hours, the extent of migration ranged from 0.25 to 13.6% area covered by cells based on the level of degradable crosslinks within the gel. It was discovered that the gel proportion containing 80% acryloylated dextran and 20% conjugated dextran limited the most cell migration.

Original languageEnglish (US)
Title of host publicationAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
EditorsR.S. Leder
Pages1203-1206
Number of pages4
Volume2
StatePublished - 2003
EventA New Beginning for Human Health: Proceddings of the 25th Annual International Conference of the IEEE Engineering in Medicine and Biology Society - Cancun, Mexico
Duration: Sep 17 2003Sep 21 2003

Other

OtherA New Beginning for Human Health: Proceddings of the 25th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Country/TerritoryMexico
CityCancun
Period9/17/039/21/03

Keywords

  • Cell migration
  • Dextran

ASJC Scopus subject areas

  • Bioengineering

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