Dextran-Based Hydrogel to Regulate Tissue Growth

D. C. Hom; Chad E. Kennedy; G. Ehteshami; Stephen Massia

Dextran-Based Hydrogel to Regulate Tissue Growth

D. C. Hom, Chad E. Kennedy, G. Ehteshami, Stephen Massia

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

A dextran hydrogel was synthesized from cross-linking a blend of acryloylated dextran and dextran bioconjugate. The conjugated dextran contains matrix metalloproteinase (MMP) sensitive peptides forming crosslinks that promotes cell-induced enzymatic degradation of the hydrogel and migration through the gel. By changing the ratio of cleavable cross-links to stable cross-links in the hydrogel, the extent of cell invasion into the gel (tissue ingrowth) can be regulated. At twenty-four hours, the extent of migration ranged from 0.25 to 13.6% area covered by cells based on the level of degradable crosslinks within the gel. It was discovered that the gel proportion containing 80% acryloylated dextran and 20% conjugated dextran limited the most cell migration.

Original language	English (US)
Title of host publication	Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
Editors	R.S. Leder
Pages	1203-1206
Number of pages	4
Volume	2
State	Published - 2003
Event	A New Beginning for Human Health: Proceddings of the 25th Annual International Conference of the IEEE Engineering in Medicine and Biology Society - Cancun, Mexico Duration: Sep 17 2003 → Sep 21 2003

Other

Other	A New Beginning for Human Health: Proceddings of the 25th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Country	Mexico
City	Cancun
Period	9/17/03 → 9/21/03

Keywords

Cell migration
Dextran

ASJC Scopus subject areas

Bioengineering

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Cite this

Hom, DC, Kennedy, CE, Ehteshami, G & Massia, S 2003, Dextran-Based Hydrogel to Regulate Tissue Growth. in RS Leder (ed.), Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. vol. 2, pp. 1203-1206, A New Beginning for Human Health: Proceddings of the 25th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, Cancun, Mexico, 9/17/03.

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abstract = "A dextran hydrogel was synthesized from cross-linking a blend of acryloylated dextran and dextran bioconjugate. The conjugated dextran contains matrix metalloproteinase (MMP) sensitive peptides forming crosslinks that promotes cell-induced enzymatic degradation of the hydrogel and migration through the gel. By changing the ratio of cleavable cross-links to stable cross-links in the hydrogel, the extent of cell invasion into the gel (tissue ingrowth) can be regulated. At twenty-four hours, the extent of migration ranged from 0.25 to 13.6% area covered by cells based on the level of degradable crosslinks within the gel. It was discovered that the gel proportion containing 80% acryloylated dextran and 20% conjugated dextran limited the most cell migration.",

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AU - Kennedy, Chad E.

AU - Ehteshami, G.

AU - Massia, Stephen

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N2 - A dextran hydrogel was synthesized from cross-linking a blend of acryloylated dextran and dextran bioconjugate. The conjugated dextran contains matrix metalloproteinase (MMP) sensitive peptides forming crosslinks that promotes cell-induced enzymatic degradation of the hydrogel and migration through the gel. By changing the ratio of cleavable cross-links to stable cross-links in the hydrogel, the extent of cell invasion into the gel (tissue ingrowth) can be regulated. At twenty-four hours, the extent of migration ranged from 0.25 to 13.6% area covered by cells based on the level of degradable crosslinks within the gel. It was discovered that the gel proportion containing 80% acryloylated dextran and 20% conjugated dextran limited the most cell migration.

AB - A dextran hydrogel was synthesized from cross-linking a blend of acryloylated dextran and dextran bioconjugate. The conjugated dextran contains matrix metalloproteinase (MMP) sensitive peptides forming crosslinks that promotes cell-induced enzymatic degradation of the hydrogel and migration through the gel. By changing the ratio of cleavable cross-links to stable cross-links in the hydrogel, the extent of cell invasion into the gel (tissue ingrowth) can be regulated. At twenty-four hours, the extent of migration ranged from 0.25 to 13.6% area covered by cells based on the level of degradable crosslinks within the gel. It was discovered that the gel proportion containing 80% acryloylated dextran and 20% conjugated dextran limited the most cell migration.

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