Dextran-Based Hydrogel to Regulate Tissue Growth

D. C. Hom; Chad E. Kennedy; G. Ehteshami; Stephen Massia

Dextran-Based Hydrogel to Regulate Tissue Growth

D. C. Hom, Chad E. Kennedy, G. Ehteshami, Stephen Massia

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

A dextran hydrogel was synthesized from cross-linking a blend of acryloylated dextran and dextran bioconjugate. The conjugated dextran contains matrix metalloproteinase (MMP) sensitive peptides forming crosslinks that promotes cell-induced enzymatic degradation of the hydrogel and migration through the gel. By changing the ratio of cleavable cross-links to stable cross-links in the hydrogel, the extent of cell invasion into the gel (tissue ingrowth) can be regulated. At twenty-four hours, the extent of migration ranged from 0.25 to 13.6% area covered by cells based on the level of degradable crosslinks within the gel. It was discovered that the gel proportion containing 80% acryloylated dextran and 20% conjugated dextran limited the most cell migration.

Original language	English (US)
Title of host publication	Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
Editors	R.S. Leder
Pages	1203-1206
Number of pages	4
Volume	2
State	Published - 2003
Event	A New Beginning for Human Health: Proceddings of the 25th Annual International Conference of the IEEE Engineering in Medicine and Biology Society - Cancun, Mexico Duration: Sep 17 2003 → Sep 21 2003

Other

Other	A New Beginning for Human Health: Proceddings of the 25th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Country/Territory	Mexico
City	Cancun
Period	9/17/03 → 9/21/03

Keywords

Cell migration
Dextran

ASJC Scopus subject areas

Bioengineering

Cite this

Hom, DC, Kennedy, CE, Ehteshami, G & Massia, S 2003, Dextran-Based Hydrogel to Regulate Tissue Growth. in RS Leder (ed.), Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. vol. 2, pp. 1203-1206, A New Beginning for Human Health: Proceddings of the 25th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, Cancun, Mexico, 9/17/03.

@inproceedings{f89a99d48dc64404a566498bc0412e97,

title = "Dextran-Based Hydrogel to Regulate Tissue Growth",

abstract = "A dextran hydrogel was synthesized from cross-linking a blend of acryloylated dextran and dextran bioconjugate. The conjugated dextran contains matrix metalloproteinase (MMP) sensitive peptides forming crosslinks that promotes cell-induced enzymatic degradation of the hydrogel and migration through the gel. By changing the ratio of cleavable cross-links to stable cross-links in the hydrogel, the extent of cell invasion into the gel (tissue ingrowth) can be regulated. At twenty-four hours, the extent of migration ranged from 0.25 to 13.6% area covered by cells based on the level of degradable crosslinks within the gel. It was discovered that the gel proportion containing 80% acryloylated dextran and 20% conjugated dextran limited the most cell migration.",

keywords = "Cell migration, Dextran",

author = "Hom, {D. C.} and Kennedy, {Chad E.} and G. Ehteshami and Stephen Massia",

year = "2003",

language = "English (US)",

volume = "2",

pages = "1203--1206",

editor = "R.S. Leder",

booktitle = "Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings",

note = "A New Beginning for Human Health: Proceddings of the 25th Annual International Conference of the IEEE Engineering in Medicine and Biology Society ; Conference date: 17-09-2003 Through 21-09-2003",

}

TY - GEN

T1 - Dextran-Based Hydrogel to Regulate Tissue Growth

AU - Hom, D. C.

AU - Kennedy, Chad E.

AU - Ehteshami, G.

AU - Massia, Stephen

PY - 2003

Y1 - 2003

N2 - A dextran hydrogel was synthesized from cross-linking a blend of acryloylated dextran and dextran bioconjugate. The conjugated dextran contains matrix metalloproteinase (MMP) sensitive peptides forming crosslinks that promotes cell-induced enzymatic degradation of the hydrogel and migration through the gel. By changing the ratio of cleavable cross-links to stable cross-links in the hydrogel, the extent of cell invasion into the gel (tissue ingrowth) can be regulated. At twenty-four hours, the extent of migration ranged from 0.25 to 13.6% area covered by cells based on the level of degradable crosslinks within the gel. It was discovered that the gel proportion containing 80% acryloylated dextran and 20% conjugated dextran limited the most cell migration.

AB - A dextran hydrogel was synthesized from cross-linking a blend of acryloylated dextran and dextran bioconjugate. The conjugated dextran contains matrix metalloproteinase (MMP) sensitive peptides forming crosslinks that promotes cell-induced enzymatic degradation of the hydrogel and migration through the gel. By changing the ratio of cleavable cross-links to stable cross-links in the hydrogel, the extent of cell invasion into the gel (tissue ingrowth) can be regulated. At twenty-four hours, the extent of migration ranged from 0.25 to 13.6% area covered by cells based on the level of degradable crosslinks within the gel. It was discovered that the gel proportion containing 80% acryloylated dextran and 20% conjugated dextran limited the most cell migration.

KW - Cell migration

KW - Dextran

UR - http://www.scopus.com/inward/record.url?scp=1542301820&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=1542301820&partnerID=8YFLogxK

M3 - Conference contribution

AN - SCOPUS:1542301820

VL - 2

SP - 1203

EP - 1206

BT - Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings

A2 - Leder, R.S.

T2 - A New Beginning for Human Health: Proceddings of the 25th Annual International Conference of the IEEE Engineering in Medicine and Biology Society

Y2 - 17 September 2003 through 21 September 2003

ER -

Dextran-Based Hydrogel to Regulate Tissue Growth

Abstract

Other

Keywords

ASJC Scopus subject areas

Other files and links

Fingerprint

Cite this