Developments in clinical islet, liver thoracic, kidney and pancreas transplantation in the last 5 years

S. Feng, M. Barr, J. Roberts, R. Oberbauer, B. Kaplan

    Research output: Contribution to journalShort surveypeer-review

    10 Scopus citations

    Abstract

    Although organ transplantation has matured into a proven therapy for end-stage organ failure, the many notable developments of the past 5 years speak to the multitude of remaining challenges. Two new procedures, islet transplantation and adult-to-adult living donor liver transplantation, have emerged to enlarge our therapeutic armamentarium for Type 1 diabetes mellitus and end-stage liver disease, respectively. In cardiac transplantation, the acceptance of ventricular assist devices as destination therapy is a notable event in light of critical shortage of deceased donor organs. Both liver and lung allocation policies have made a dramatic paradigm shift away from waiting time toward the survival benefit of transplantation. Finally, primary threats to post-transplant longevity have gained an increasing share of the spotlight. Recognition of the impact of renal insufficiency for all nonrenal transplant recipients, of recurrent hepatitis C virus for liver recipients, and of accelerated vasculopathy for cardiac have identified novel end points for clinical trials.

    Original languageEnglish (US)
    Pages (from-to)1759-1767
    Number of pages9
    JournalAmerican Journal of Transplantation
    Volume6
    Issue number8
    DOIs
    StatePublished - Aug 1 2006

    Keywords

    • Allocation policy
    • MELD
    • Minimization protocols
    • Recurrent hepatitis C
    • Sirolimus
    • Steroid avoidance

    ASJC Scopus subject areas

    • Immunology and Allergy
    • Transplantation
    • Pharmacology (medical)

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