TY - JOUR
T1 - Developmental Systems Drift and the Drivers of Sex Chromosome Evolution
AU - Cauret, Caroline M.S.
AU - Gansauge, Marie Theres
AU - Tupper, Andrew S.
AU - Furman, Benjamin L.S.
AU - Knytl, Martin
AU - Song, Xue Ying
AU - Greenbaum, Eli
AU - Meyer, Matthias
AU - Evans, Ben J.
AU - Wilson, Melissa
N1 - Funding Information:
We are especially grateful to Svante P€a€abo and Max Planck Institute for Evolutionary Anthropology for hosting B.J.E. on a sabbatical in Leipzig, Germany. We thank Darcy Kelley for providing us with X. mellotropicalis and X. clivii individuals, Ben Vernot for assistance with capture probe design, Birgit Nickel for performing library capture, Brian Golding and the Shared Hierarchical Academic Research Computing Network (SHARCNET: www.sharcnet.ca) and Compute/Calcul Canada for access to computational resources, and Brian Golding, Jonathan Dushoff, Ian Dworkin, and four anonymous reviewers for enlightening discussions and comments on a draft of this article. This work was supported by the Natural Science and Engineering Research Council of Canada (RGPIN/ 283102-2012 and RGPIN-2017-05770 to B.J.E.), the Museum of Comparative Zoology (B.J.E.), the Max Planck Institute for Evolutionary Anthropology (M.-T.G., M.M., B.J.E.), a National Geographic Research and Exploration Grant (no. 8556-08 to E.G.), and the US National Science Foundation (DEB-1145459 to E.G.).
Publisher Copyright:
© 2019 The Author(s). Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution. All rights reserved.
PY - 2020/3/1
Y1 - 2020/3/1
N2 - Phenotypic invariance-the outcome of purifying selection-is a hallmark of biological importance. However, invariant phenotypes might be controlled by diverged genetic systems in different species. Here, we explore how an important and invariant phenotype-the development of sexually differentiated individuals-is controlled in over two dozen species in the frog family Pipidae. We uncovered evidence in different species for 1) an ancestral W chromosome that is not found in many females and is found in some males, 2) independent losses and 3) autosomal segregation of this W chromosome, 4) changes in male versus female heterogamy, and 5) substantial variation among species in recombination suppression on sex chromosomes. We further provide evidence of, and evolutionary context for, the origins of at least seven distinct systems for regulating sex determination among three closely related genera. These systems are distinct in their genomic locations, evolutionary origins, and/or male versus female heterogamy. Our findings demonstrate that the developmental control of sexual differentiation changed via loss, sidelining, and empowerment of a mechanistically influential gene, and offer insights into novel factors that impinge on the diverse evolutionary fates of sex chromosomes.
AB - Phenotypic invariance-the outcome of purifying selection-is a hallmark of biological importance. However, invariant phenotypes might be controlled by diverged genetic systems in different species. Here, we explore how an important and invariant phenotype-the development of sexually differentiated individuals-is controlled in over two dozen species in the frog family Pipidae. We uncovered evidence in different species for 1) an ancestral W chromosome that is not found in many females and is found in some males, 2) independent losses and 3) autosomal segregation of this W chromosome, 4) changes in male versus female heterogamy, and 5) substantial variation among species in recombination suppression on sex chromosomes. We further provide evidence of, and evolutionary context for, the origins of at least seven distinct systems for regulating sex determination among three closely related genera. These systems are distinct in their genomic locations, evolutionary origins, and/or male versus female heterogamy. Our findings demonstrate that the developmental control of sexual differentiation changed via loss, sidelining, and empowerment of a mechanistically influential gene, and offer insights into novel factors that impinge on the diverse evolutionary fates of sex chromosomes.
KW - developmental systems drift
KW - recombination suppression
KW - sex chromosomes
KW - sexual antagonism
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U2 - 10.1093/molbev/msz268
DO - 10.1093/molbev/msz268
M3 - Article
C2 - 31710681
AN - SCOPUS:85077933249
SN - 0737-4038
VL - 37
SP - 799
EP - 810
JO - Molecular biology and evolution
JF - Molecular biology and evolution
IS - 3
ER -