Development of Search Strategy for Peptide Inhibitors of Immune Checkpoints

S. V. Podlesnykh, D. V. Shanshin, E. A. Kolosova, D. E. Murashkin, O. N. Shaprova, D. N. Shcherbakov, Andrei Chapoval

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Current strategy for the blockade of molecules inhibiting T-cell immunity, the immune checkpoints (ICP), such as CTLA-4, PD-1, and B7-H1(PD-L1), using monoclonal antibodies (mAbs), showed significant clinical effects in cancer immunotherapy. In this kind of therapy, antibodies do not kill tumor cells directly, but block inhibitory signals for T lymphocytes, resulting in activation of the immune response cascade that eliminate malignant cells and lead to tumor degradation. However, the mAb preparations have some limitations, and the development of new low-molecular-weight antagonists (for example, peptides) is an important issue. In this study, we used peptide microarrays and phage display libraries to search for peptides that interact with the immune checkpoints. We found peptides that specifically bind CTLA-4, PD-1, B7-1, B7-2 and B7-H1(PD-L1) which play important role in the regulation of the immune responses. These synthetic peptides can be applied to the development of new immunomodulating drugs for cancer immunotherapy.

Original languageEnglish (US)
Pages (from-to)150-157
Number of pages8
JournalRussian Journal of Bioorganic Chemistry
Volume44
Issue number2
DOIs
StatePublished - Mar 1 2018

Keywords

  • co-stimulatory molecules
  • immune checkpoints
  • immune response
  • immunomodulation
  • immunotherapy
  • peptide microchips
  • phage display
  • synthetic peptides

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry

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  • Cite this

    Podlesnykh, S. V., Shanshin, D. V., Kolosova, E. A., Murashkin, D. E., Shaprova, O. N., Shcherbakov, D. N., & Chapoval, A. (2018). Development of Search Strategy for Peptide Inhibitors of Immune Checkpoints. Russian Journal of Bioorganic Chemistry, 44(2), 150-157. https://doi.org/10.1134/S1068162018020024