Development of community of practice to support quantitative risk assessment for synthetic biology products: contaminant bioremediation and invasive carp control as cases

Benjamin D. Trump, Christy Foran, Taylor Rycroft, Matthew D. Wood, Nirzwan Bandolin, Mariana Cains, Timothy Cary, Fiona Crocker, Nicholas A. Friedenberg, Patrick Gurian, Kerry Hamilton, Jan Jeffrey Hoover, Corey Meyer, Kaytee Pokrzywinski, Ryan Ritterson, Paul Schulte, Christopher Warner, Edward Perkins, Igor Linkov

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Synthetic biology has the potential for a broad array of applications. However, realization of this potential is challenged by the paucity of relevant data for conventional risk assessment protocols, a limitation due to to the relative nascence of the field, as well as the poorly characterized and prioritized hazard, exposure, and dose–response considerations associated with the development and use of synthetic biology-derived organisms. Where quantitative risk assessment approaches are necessarily to fulfill regulatory requirements for review of products containing genetically modified organisms, this paper reviews one potential avenue for early-stage quantitative risk assessment for biosafety considerations of synthetic biology organism deployment into the environment. Building from discussion from a March 2018 US Army Engineer Research and Development Center workshop on developing such quantitative risk assessment for synthetic biology, this paper reviews the findings and discussion of workshop participants. This paper concludes that, while synthetic biology risk assessment and governance will continue to refine and develop in the coming years, a quantitative framework that builds from existing practice is one potentially beneficial option for risk assessors that must contend with the technology’s limited hazard characterization or exposure assessment considerations in the near term.

Original languageEnglish (US)
Pages (from-to)517-527
Number of pages11
JournalEnvironment Systems and Decisions
Volume38
Issue number4
DOIs
StatePublished - Dec 1 2018

Keywords

  • Risk assessment
  • Synthetic biology
  • Technology governance

ASJC Scopus subject areas

  • Environmental Science(all)

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