Development of cell-mediated immunity to marek’s disease tumor cells in chickens inoculated with marek’s disease vaccines

J. M. Sharma, R. L. Witter, B. D. Coulson

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

Chickens Inoculated with herpesvirus of turkeys or with apathogenlc or attenuated vaccine strains of Marek’s disease virus (MDV) developed a T-cell-medlated Immune response to Marek’s disease (MD) tumor cells. This Immune response was detected In a 4-hour 51Cr-release assay In which effector cells obtained from spleens of vaccinated chickens were reacted with 51Cr-labeled target cells of an MD lymphoblastoid cell line (MSB- 1). The cytotoxic effector cells generated by the vaccine viruses had characteristics similar to those noted previously for antl- MSB-1 effector cells generated by MDV. The immune response was specific to MSB-1 cells, because another target cell line (TLT) antlgenically unrelated to MSB-1 cells was not lysed by the effector cells nor did the unrelated target cells inhibit the cytotoxicity of effector cells against MSB-1 target in a cold-target Inhibition assay. Because MSB-1 cells contain MD tumor-associated surface antigen, we postulated that the Immune response detected in the vaccinated chickens may be directed against this antigen and that the antitumor antigen Immunity may play a role in the mechanism of vaccine protection against lymphoma development by pathogenic MDV.—J Natl Cancer Inst 61: 1273- 1280, 1978.

Original languageEnglish (US)
Pages (from-to)1273-1280
Number of pages8
JournalJournal of the National Cancer Institute
Volume61
Issue number5
DOIs
StatePublished - Nov 1978

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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