Development of autoimmune hepatitis in the setting of long-standing primary biliary cirrhosis

Paul Angulo, Omer El-Amin, Herschel A. Carpenter, Keith Lindor

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Primary biliary cirrhosis and autoimmune hepatitis, the most common autoimmune liver diseases in adults, are frequently easily differentiated by a combination of clinical, biochemical, and histological features along with the presence of highly sensitive and characteristic serum autoantibodies. Patients presenting with "overlapping" features of both conditions simultaneously are not uncommon. However, patients who switch over time from one disease to another have remained largely unrecognized. We report here two cases from the spectrum of autoimmune liver disease, patients who had well-defined primary biliary cirrhosis for a number of years and then developed the classic picture of superimposed autoimmune hepatitis. The importance of its recognition and the appropriate management modifications are discussed.

Original languageEnglish (US)
Pages (from-to)3021-3027
Number of pages7
JournalAmerican Journal of Gastroenterology
Volume96
Issue number10
DOIs
StatePublished - 2001
Externally publishedYes

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Autoimmune Hepatitis
Biliary Liver Cirrhosis
Autoimmune Diseases
Liver Diseases
Autoantibodies
Serum

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Development of autoimmune hepatitis in the setting of long-standing primary biliary cirrhosis. / Angulo, Paul; El-Amin, Omer; Carpenter, Herschel A.; Lindor, Keith.

In: American Journal of Gastroenterology, Vol. 96, No. 10, 2001, p. 3021-3027.

Research output: Contribution to journalArticle

Angulo, Paul ; El-Amin, Omer ; Carpenter, Herschel A. ; Lindor, Keith. / Development of autoimmune hepatitis in the setting of long-standing primary biliary cirrhosis. In: American Journal of Gastroenterology. 2001 ; Vol. 96, No. 10. pp. 3021-3027.
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