Development of Antibody-Based Therapeutics Against West Nile Virus in Plants

Haiyan Sun, Josh Lesio, Qiang Chen

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Abstract

Since its discovery in 1937 in the West Nile district of Uganda, West Nile virus (WNV) has been one of the leading causes of mosquito-transmitted infectious diseases (Smithburn, Burke, Am J Trop Med 20:22, 1940). Subsequently, it spread to Europe, Asia, Australia, and finally North America in 1999 (Sejvar, Ochsner 5(3):6–10, 2003). Worldwide outbreaks have continued to increase since the 1990s (Chancey et al, Biomed Res Int 2015:376230, 2015). According to the Center for Disease Control and Prevention, more than 51,000 cases of WNV infection and nearly 2400 cases of WNV-related death were reported in the USA from 1999 to 2019. The estimated economic impact of WNV infections is close to 800 million dollars in the USA from 1999 to 2012 (Barrett, Am J Trop Med Hyg 90:389, 2014).

Original languageEnglish (US)
Title of host publicationMethods in Molecular Biology
PublisherHumana Press Inc.
Pages211-225
Number of pages15
DOIs
StatePublished - 2023
Externally publishedYes

Publication series

NameMethods in Molecular Biology
Volume2585
ISSN (Print)1064-3745
ISSN (Electronic)1940-6029

Keywords

  • Monoclonal antibody (mAb)
  • Plant expression system
  • Plant-derived antibody
  • Plant-made biologics
  • West Nile virus

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

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