TY - CHAP
T1 - Development of Antibody-Based Therapeutics Against West Nile Virus in Plants
AU - Sun, Haiyan
AU - Lesio, Josh
AU - Chen, Qiang
N1 - Funding Information:
The work from the Chen laboratory reported in this chapter was supported in part by grants from the National Institute of Allergy and Infectious Diseases (NIAID) # U01 AI075549 and # R33AI101329 to QC.
Publisher Copyright:
© 2023, The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature.
PY - 2023
Y1 - 2023
N2 - Since its discovery in 1937 in the West Nile district of Uganda, West Nile virus (WNV) has been one of the leading causes of mosquito-transmitted infectious diseases (Smithburn, Burke, Am J Trop Med 20:22, 1940). Subsequently, it spread to Europe, Asia, Australia, and finally North America in 1999 (Sejvar, Ochsner 5(3):6–10, 2003). Worldwide outbreaks have continued to increase since the 1990s (Chancey et al, Biomed Res Int 2015:376230, 2015). According to the Center for Disease Control and Prevention, more than 51,000 cases of WNV infection and nearly 2400 cases of WNV-related death were reported in the USA from 1999 to 2019. The estimated economic impact of WNV infections is close to 800 million dollars in the USA from 1999 to 2012 (Barrett, Am J Trop Med Hyg 90:389, 2014).
AB - Since its discovery in 1937 in the West Nile district of Uganda, West Nile virus (WNV) has been one of the leading causes of mosquito-transmitted infectious diseases (Smithburn, Burke, Am J Trop Med 20:22, 1940). Subsequently, it spread to Europe, Asia, Australia, and finally North America in 1999 (Sejvar, Ochsner 5(3):6–10, 2003). Worldwide outbreaks have continued to increase since the 1990s (Chancey et al, Biomed Res Int 2015:376230, 2015). According to the Center for Disease Control and Prevention, more than 51,000 cases of WNV infection and nearly 2400 cases of WNV-related death were reported in the USA from 1999 to 2019. The estimated economic impact of WNV infections is close to 800 million dollars in the USA from 1999 to 2012 (Barrett, Am J Trop Med Hyg 90:389, 2014).
KW - Monoclonal antibody (mAb)
KW - Plant expression system
KW - Plant-derived antibody
KW - Plant-made biologics
KW - West Nile virus
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U2 - 10.1007/978-1-0716-2760-0_19
DO - 10.1007/978-1-0716-2760-0_19
M3 - Chapter
C2 - 36331777
AN - SCOPUS:85141693169
T3 - Methods in Molecular Biology
SP - 211
EP - 225
BT - Methods in Molecular Biology
PB - Humana Press Inc.
ER -