Development of an avian model for restenosis

Alexandra Lucas, Wen Yue, Xiu Yan Jiang, Li Ying Liu, Wei Dong Yan, Jim Bauer, Wolfgang Schneider, John Tulip, Anees Chagpar, Erbin Dai, Masis Perk, Patricia Montague, Michael Garbutt, Markus Radosavljevic

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

Recurrence of atherosclerotic plaque growth after interventional therapy, restenosis, is a significant clinical problem occurring in 20%-50% of cases. We have developed a new avian model for the investigation of restenosis after arterial injury in cholesterol fed White Leghorn roosters. Atherosclerotic plaque growth 1-30 weeks after angioplasty balloon mediated endothelial injury in the abdominal aorta was studied in 37 roosters. Roosters were maintained on either normal poultry diet or high cholesterol diet. Twelve cholesterol fed roosters were also fed a hormone supplemented diet in order to modify plaque morphology. The procedural success rate was high. Angiographic stenoses (mean 36% with maximum of 74%) were detectable in cholesterol fed roosters after balloon angioplasty with associated histological evidence of plaque growth (P < 0.017). Cholesterol feeding enhanced fatty plaque growth; hormone manipulation increased calcific and ulcerated plaque but with high associated morbidity. Three interventional devices were subsequently examined in 32 roosters (16 laser angioplasty, 7 atherectomy, and 9 stent implant). Plaque development was again assessed by contrast angiography and histological analysis. We conclude that balloon mediated arterial injury in cholesterol fed roosters produces early proliferative and late, complex atherosclerotic lesions providing an inexpensive model for plaque development after intimal injury.

Original languageEnglish (US)
Pages (from-to)17-41
Number of pages25
JournalAtherosclerosis
Volume119
Issue number1
DOIs
StatePublished - Jan 5 1996
Externally publishedYes

Keywords

  • Atherosclerosis
  • Avian model
  • Restenosis

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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