Development of a general approach to the synthesis of a library of isoflavonoid derivatives

Kyle F. Biegasiewicz, James S. Gordon, Deana A. Rodriguez, Ronny Priefer

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

Isoflavonoids are a class of organic compounds that act primarily as antioxidants. They are produced almost exclusively by various members of the bean family including soybeans, tofu, peanuts, chick peas, and alfalfa. The antioxidant characteristics that isoflavonoids exhibit help hinder the progression of certain cancers, primarily breast, prostate, and colon cancer. We have developed a three-five step synthesis for obtaining a suite of isoflavonoid derivatives. The synthesis involves an enamine formation, a ring closure and halogenation, a Suzuki coupling, and finally a global deprotection to obtain the respective isoflavonoid derivatives.

Original languageEnglish (US)
Pages (from-to)5210-5212
Number of pages3
JournalTetrahedron Letters
Volume55
Issue number37
DOIs
StatePublished - Jul 2005
Externally publishedYes

Keywords

  • Green chemistry
  • Isoflavonoids
  • Ring closure
  • Suzuki coupling

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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