Abstract
Isoflavonoids are a class of organic compounds that act primarily as antioxidants. They are produced almost exclusively by various members of the bean family including soybeans, tofu, peanuts, chick peas, and alfalfa. The antioxidant characteristics that isoflavonoids exhibit help hinder the progression of certain cancers, primarily breast, prostate, and colon cancer. We have developed a three-five step synthesis for obtaining a suite of isoflavonoid derivatives. The synthesis involves an enamine formation, a ring closure and halogenation, a Suzuki coupling, and finally a global deprotection to obtain the respective isoflavonoid derivatives.
Original language | English (US) |
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Pages (from-to) | 5210-5212 |
Number of pages | 3 |
Journal | Tetrahedron Letters |
Volume | 55 |
Issue number | 37 |
DOIs | |
State | Published - Jul 2005 |
Externally published | Yes |
Keywords
- Green chemistry
- Isoflavonoids
- Ring closure
- Suzuki coupling
ASJC Scopus subject areas
- Biochemistry
- Drug Discovery
- Organic Chemistry