TY - JOUR
T1 - Developing and interpreting aqueous functional assays for comparative property-activity relationships of different nanoparticles
AU - Kidd, Justin M.
AU - Hanigan, David
AU - Truong, Lisa
AU - Hristovski, Kiril
AU - Tanguay, Robert
AU - Westerhoff, Paul
N1 - Publisher Copyright:
© 2018 Elsevier B.V.
PY - 2018/7/1
Y1 - 2018/7/1
N2 - It is difficult to relate intrinsic nanomaterial properties to their functional behavior in the environment. Unlike frameworks for dissolved organic chemicals, there are few frameworks comparing multiple and inter-related properties of engineered nanomaterials (ENMs) to their fate, exposure, and hazard in environmental systems. We developed and evaluated reproducibility and inter-correlation of 12 physical, chemical, and biological functional assays in water for eight different engineered nanomaterials (ENMs) and interpreted results using activity-profiling radar plots. The functional assays were highly reproducible when run in triplicate (average coefficient of variation [CV] = 6.6%). Radar plots showed that each nanomaterial exhibited unique activity profiles. Reactivity assays showed dissolution or aggregation potential for some ENMs. Surprisingly, multi-walled carbon nanotubes (MWCNTs) exhibited movement in a magnetic field. We found high inter-correlations between cloud point extraction (CPE) and distribution to sewage sludge (R2 = 0.99), dissolution at pH 8 and pH 4.9 (R2 = 0.98), and dissolution at pH 8 and zebrafish mortality at 24 hpf (R2 = 0.94). Additionally, most ENMs tend to distribute out of water and into other phases (i.e., soil surfaces, surfactant micelles, and sewage sludge). The activity-profiling radar plots provide a framework and estimations of likely ENM disposition in the environment.
AB - It is difficult to relate intrinsic nanomaterial properties to their functional behavior in the environment. Unlike frameworks for dissolved organic chemicals, there are few frameworks comparing multiple and inter-related properties of engineered nanomaterials (ENMs) to their fate, exposure, and hazard in environmental systems. We developed and evaluated reproducibility and inter-correlation of 12 physical, chemical, and biological functional assays in water for eight different engineered nanomaterials (ENMs) and interpreted results using activity-profiling radar plots. The functional assays were highly reproducible when run in triplicate (average coefficient of variation [CV] = 6.6%). Radar plots showed that each nanomaterial exhibited unique activity profiles. Reactivity assays showed dissolution or aggregation potential for some ENMs. Surprisingly, multi-walled carbon nanotubes (MWCNTs) exhibited movement in a magnetic field. We found high inter-correlations between cloud point extraction (CPE) and distribution to sewage sludge (R2 = 0.99), dissolution at pH 8 and pH 4.9 (R2 = 0.98), and dissolution at pH 8 and zebrafish mortality at 24 hpf (R2 = 0.94). Additionally, most ENMs tend to distribute out of water and into other phases (i.e., soil surfaces, surfactant micelles, and sewage sludge). The activity-profiling radar plots provide a framework and estimations of likely ENM disposition in the environment.
KW - Exposure
KW - Fate
KW - Hazard
KW - Nanoparticle
KW - Water
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U2 - 10.1016/j.scitotenv.2018.02.107
DO - 10.1016/j.scitotenv.2018.02.107
M3 - Article
C2 - 30045577
AN - SCOPUS:85042386801
SN - 0048-9697
VL - 628-629
SP - 1609
EP - 1616
JO - Science of the Total Environment
JF - Science of the Total Environment
ER -