Detection of Tumor Targeting with Bleomycin-Derivatized Microbubbles

Sidney Hecht (Inventor)

Research output: Patent

Abstract

ASU researchers have identified new methods and compositions to directly target therapeutics to tumors while also performing diagnostic imaging. Ultrasound contrast agent materials are combined with glycopeptide-based antibiotics in a unique formulation capable of simultaneous targeting of therapeutics and selective imaging. Traditionally used with ultrasound technology for in-vivo imaging, microbubbles typically consist of a shell comprised of albumin, galactose or lipids enclosing a gas core. Microbubbles are administrated intravenously to the systemic circulation, their echogenocity allows contrast-enhanced ultrasound and improved medical sonography. In medical imaging, these agents have applications in radiology and cardiology. By utilizing a new and novel combination of antibiotic therapeutic and attachment chemistries, ASU researchers have created a range of new materials useful for drug delivery to tumor sites, while offering the capability for selective in-vivo imaging and therapy monitoring. Appropriate selection of microbubble functionalization enables targeting of the delivery agent, therapy delivery and treatment monitoring. Chemistries can be selected to enable one, or a combination of these functions. Although the current focus is on existing clinical therapeutics for use in treating malignant cancer cells, the platform offers significant flexibility in type and number of therapeutic agents, and attachment methodologies for various diagnostic and therapeutic applications. Potential Applications Cancer-therapeutics Drug-delivery Therapeutic monitoring Tissue Imaging Benefits and Advantages Ease of use - Does not use radionuclides Builds on well-established technologies for tissue imaging Flexibility platform for expansion of therapeutic / diagnostic application Download original PDF For more information about the inventor(s) and their research, please see Dr. Hecht's departmental webpage
Original languageEnglish (US)
StatePublished - Sep 26 2008

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Microbubbles
Bleomycin
Neoplasms
Therapeutics
Diagnostic Imaging
Contrast Media
Inventors
Research Personnel
Anti-Bacterial Agents
Technology
Glycopeptides
Drug Monitoring
Therapeutic Uses
Cardiology
Galactose
Radiology
Radioisotopes
Albumins
Ultrasonography
Gases

Cite this

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title = "Detection of Tumor Targeting with Bleomycin-Derivatized Microbubbles",
abstract = "ASU researchers have identified new methods and compositions to directly target therapeutics to tumors while also performing diagnostic imaging. Ultrasound contrast agent materials are combined with glycopeptide-based antibiotics in a unique formulation capable of simultaneous targeting of therapeutics and selective imaging. Traditionally used with ultrasound technology for in-vivo imaging, microbubbles typically consist of a shell comprised of albumin, galactose or lipids enclosing a gas core. Microbubbles are administrated intravenously to the systemic circulation, their echogenocity allows contrast-enhanced ultrasound and improved medical sonography. In medical imaging, these agents have applications in radiology and cardiology. By utilizing a new and novel combination of antibiotic therapeutic and attachment chemistries, ASU researchers have created a range of new materials useful for drug delivery to tumor sites, while offering the capability for selective in-vivo imaging and therapy monitoring. Appropriate selection of microbubble functionalization enables targeting of the delivery agent, therapy delivery and treatment monitoring. Chemistries can be selected to enable one, or a combination of these functions. Although the current focus is on existing clinical therapeutics for use in treating malignant cancer cells, the platform offers significant flexibility in type and number of therapeutic agents, and attachment methodologies for various diagnostic and therapeutic applications. Potential Applications Cancer-therapeutics Drug-delivery Therapeutic monitoring Tissue Imaging Benefits and Advantages Ease of use - Does not use radionuclides Builds on well-established technologies for tissue imaging Flexibility platform for expansion of therapeutic / diagnostic application Download original PDF For more information about the inventor(s) and their research, please see Dr. Hecht's departmental webpage",
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language = "English (US)",
type = "Patent",

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AB - ASU researchers have identified new methods and compositions to directly target therapeutics to tumors while also performing diagnostic imaging. Ultrasound contrast agent materials are combined with glycopeptide-based antibiotics in a unique formulation capable of simultaneous targeting of therapeutics and selective imaging. Traditionally used with ultrasound technology for in-vivo imaging, microbubbles typically consist of a shell comprised of albumin, galactose or lipids enclosing a gas core. Microbubbles are administrated intravenously to the systemic circulation, their echogenocity allows contrast-enhanced ultrasound and improved medical sonography. In medical imaging, these agents have applications in radiology and cardiology. By utilizing a new and novel combination of antibiotic therapeutic and attachment chemistries, ASU researchers have created a range of new materials useful for drug delivery to tumor sites, while offering the capability for selective in-vivo imaging and therapy monitoring. Appropriate selection of microbubble functionalization enables targeting of the delivery agent, therapy delivery and treatment monitoring. Chemistries can be selected to enable one, or a combination of these functions. Although the current focus is on existing clinical therapeutics for use in treating malignant cancer cells, the platform offers significant flexibility in type and number of therapeutic agents, and attachment methodologies for various diagnostic and therapeutic applications. Potential Applications Cancer-therapeutics Drug-delivery Therapeutic monitoring Tissue Imaging Benefits and Advantages Ease of use - Does not use radionuclides Builds on well-established technologies for tissue imaging Flexibility platform for expansion of therapeutic / diagnostic application Download original PDF For more information about the inventor(s) and their research, please see Dr. Hecht's departmental webpage

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