TY - JOUR
T1 - Detection of trace levels of lead in aqueous liquids using extractive electrospray ionization tandem mass spectrometry
AU - Liu, Chunxiao
AU - Zhang, Xinglei
AU - Xiao, Saijin
AU - Jia, Bin
AU - Cui, Shasha
AU - Shi, Jianbo
AU - Xu, Ning
AU - Xie, Xi
AU - Gu, Haiwei
AU - Chen, Huanwen
N1 - Funding Information:
This work was supported by Chinese National Science Foundation (No. 21005015 and No. 20827007 ) and Chinese National Instrumentation Program ( 2011YQ170067 ).
PY - 2012/8/30
Y1 - 2012/8/30
N2 - A sensitive approach, based on semi-quantitative measurement of the characteristic fragments in multi-stage extractive electrospray ionization mass spectrometry (EESI-MSn), was developed for fast detection of trace levels of lead in aqueous liquids including mineral water, lake water, tap water, energy drinks, soft drinks, beer, orange juice, and tea. A disodium ethylene-diamine-tetraacetic acid (EDTA) aqueous solution was electrosprayed to produce negatively charged primary ions which then intersected the neutral sample plume to generate anions of EDTA-Pb(II) complexes. The charged EDTA-Pb(II) complexes were characterized with multistage collision induced dissociation (CID) experiments. The limit of detection (LOD) using EESI-MS 3 was estimated to be at the level of 10-13 g/mL for directly detecting lead in many of these samples. The linear dynamic range was higher than 2 orders of magnitude. A single sample analysis could be completed within 2 min with reasonable semi-quantitative performance, e.g., relative standard deviations (RSDs) for deionized water were 4.6-7.6% during 5 experimental runs (each of them had 10 repeated measurements). Coca-cola and Huiyuan orange juice, representative beverage samples with complex matrices, generated recovery rates of 91.5% and 129%, respectively. Our experimental data demonstrated that EESI-MS is a useful tool for the fast detection of lead in various solutions, and EESI-MS showed promises for fast screening of lead-contaminated aqueous liquid samples.
AB - A sensitive approach, based on semi-quantitative measurement of the characteristic fragments in multi-stage extractive electrospray ionization mass spectrometry (EESI-MSn), was developed for fast detection of trace levels of lead in aqueous liquids including mineral water, lake water, tap water, energy drinks, soft drinks, beer, orange juice, and tea. A disodium ethylene-diamine-tetraacetic acid (EDTA) aqueous solution was electrosprayed to produce negatively charged primary ions which then intersected the neutral sample plume to generate anions of EDTA-Pb(II) complexes. The charged EDTA-Pb(II) complexes were characterized with multistage collision induced dissociation (CID) experiments. The limit of detection (LOD) using EESI-MS 3 was estimated to be at the level of 10-13 g/mL for directly detecting lead in many of these samples. The linear dynamic range was higher than 2 orders of magnitude. A single sample analysis could be completed within 2 min with reasonable semi-quantitative performance, e.g., relative standard deviations (RSDs) for deionized water were 4.6-7.6% during 5 experimental runs (each of them had 10 repeated measurements). Coca-cola and Huiyuan orange juice, representative beverage samples with complex matrices, generated recovery rates of 91.5% and 129%, respectively. Our experimental data demonstrated that EESI-MS is a useful tool for the fast detection of lead in various solutions, and EESI-MS showed promises for fast screening of lead-contaminated aqueous liquid samples.
KW - Ambient mass spectrometry
KW - Beverage
KW - Extractive electrospray ionization
KW - Lead
KW - Tandem mass spectrometry
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U2 - 10.1016/j.talanta.2012.06.048
DO - 10.1016/j.talanta.2012.06.048
M3 - Article
C2 - 22939131
AN - SCOPUS:84865689777
SN - 0039-9140
VL - 98
SP - 79
EP - 85
JO - Talanta
JF - Talanta
ER -