167 Scopus citations


We have built a high-resolution differential surface plasmon resonance (SPR) sensor for heavy metal ion detection. The sensor surface is divided into a reference and sensing areas, and the difference in the SPR angles from the two areas is detected with a quadrant cell photodetector as a differential signal. In the presence of metal ions, the differential signal changes due to specific binding of the metal ions onto the sensing area coated with properly selected peptides, which provides an accurate real-time measurement and quantification of the metal ions. Selective detection of Cu2+ and Ni2+ in the ppt-ppb range was achieved by coating the sensing surface with peptides NH2-Gly-Gly-His-COOH and NH2-(His)6-COOH. Cu2+ in drinking water was tested using this sensor.

Original languageEnglish (US)
Pages (from-to)1257-1262
Number of pages6
JournalEnvironmental Science and Technology
Issue number5
StatePublished - Mar 1 2005

ASJC Scopus subject areas

  • Chemistry(all)
  • Environmental Chemistry

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