Detecting signatures of inter-regional and inter-specific hybridization among the Chinese rhesus macaque specific pathogen-free (SPF) population using single nucleotide polymorphic (SNP) markers

Sreetharan Kanthaswamy, Jessica Satkoski, Alex Kou, Venkat Malladi, David Glenn Smith

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Background: While rates of gene flow between rhesus and longtail macaque populations near their hybrid zone in Indochina have been quantified elsewhere, this study demonstrates that the inter-specific introgression is not limited to the Indochinese hybrid zone but is more geographically widespread. Methods: Twelve rhesus and longtail macaque populations were analyzed using single nucleotide polymorphic (SNP) loci. Results: There is evidence for inter-specific admixture between Chinese rhesus and mainland longtails, with implications for genetic diversity both in the Chinese super-SPF population at the California National Primate Research Center and in other primate facilities. Eastern Chinese rhesus appeared more highly derived than western Chinese rhesus, and allele sharing between longtails and Chinese rhesus was not random with regard to geographic distance, but no significant nuclear genetic differences between eastern and western Chinese rhesus were detected among the 245 genic SNPs assayed. Conclusion: The implications of this inter-specific admixture for the use of Chinese rhesus and mainland longtail in biomedical research should be considered.

Original languageEnglish (US)
Pages (from-to)252-265
Number of pages14
JournalJournal of Medical Primatology
Volume39
Issue number4
DOIs
StatePublished - 2010
Externally publishedYes

Fingerprint

Specific Pathogen-Free Organisms
interspecific hybridization
Macaca mulatta
Nucleotides
nucleotides
Macaca
Primates
pathogens
Population
Indochina
Gene Flow
biomedical research
introgression
Single Nucleotide Polymorphism
Biomedical Research
gene flow
Alleles
alleles
genetic variation
loci

Keywords

  • Genetic admixture
  • Macaca fascicularis
  • Macaca mulatta
  • Phylogenetics
  • Population genetics

ASJC Scopus subject areas

  • Animal Science and Zoology
  • veterinary(all)
  • Medicine(all)

Cite this

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title = "Detecting signatures of inter-regional and inter-specific hybridization among the Chinese rhesus macaque specific pathogen-free (SPF) population using single nucleotide polymorphic (SNP) markers",
abstract = "Background: While rates of gene flow between rhesus and longtail macaque populations near their hybrid zone in Indochina have been quantified elsewhere, this study demonstrates that the inter-specific introgression is not limited to the Indochinese hybrid zone but is more geographically widespread. Methods: Twelve rhesus and longtail macaque populations were analyzed using single nucleotide polymorphic (SNP) loci. Results: There is evidence for inter-specific admixture between Chinese rhesus and mainland longtails, with implications for genetic diversity both in the Chinese super-SPF population at the California National Primate Research Center and in other primate facilities. Eastern Chinese rhesus appeared more highly derived than western Chinese rhesus, and allele sharing between longtails and Chinese rhesus was not random with regard to geographic distance, but no significant nuclear genetic differences between eastern and western Chinese rhesus were detected among the 245 genic SNPs assayed. Conclusion: The implications of this inter-specific admixture for the use of Chinese rhesus and mainland longtail in biomedical research should be considered.",
keywords = "Genetic admixture, Macaca fascicularis, Macaca mulatta, Phylogenetics, Population genetics",
author = "Sreetharan Kanthaswamy and Jessica Satkoski and Alex Kou and Venkat Malladi and {Glenn Smith}, David",
year = "2010",
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TY - JOUR

T1 - Detecting signatures of inter-regional and inter-specific hybridization among the Chinese rhesus macaque specific pathogen-free (SPF) population using single nucleotide polymorphic (SNP) markers

AU - Kanthaswamy, Sreetharan

AU - Satkoski, Jessica

AU - Kou, Alex

AU - Malladi, Venkat

AU - Glenn Smith, David

PY - 2010

Y1 - 2010

N2 - Background: While rates of gene flow between rhesus and longtail macaque populations near their hybrid zone in Indochina have been quantified elsewhere, this study demonstrates that the inter-specific introgression is not limited to the Indochinese hybrid zone but is more geographically widespread. Methods: Twelve rhesus and longtail macaque populations were analyzed using single nucleotide polymorphic (SNP) loci. Results: There is evidence for inter-specific admixture between Chinese rhesus and mainland longtails, with implications for genetic diversity both in the Chinese super-SPF population at the California National Primate Research Center and in other primate facilities. Eastern Chinese rhesus appeared more highly derived than western Chinese rhesus, and allele sharing between longtails and Chinese rhesus was not random with regard to geographic distance, but no significant nuclear genetic differences between eastern and western Chinese rhesus were detected among the 245 genic SNPs assayed. Conclusion: The implications of this inter-specific admixture for the use of Chinese rhesus and mainland longtail in biomedical research should be considered.

AB - Background: While rates of gene flow between rhesus and longtail macaque populations near their hybrid zone in Indochina have been quantified elsewhere, this study demonstrates that the inter-specific introgression is not limited to the Indochinese hybrid zone but is more geographically widespread. Methods: Twelve rhesus and longtail macaque populations were analyzed using single nucleotide polymorphic (SNP) loci. Results: There is evidence for inter-specific admixture between Chinese rhesus and mainland longtails, with implications for genetic diversity both in the Chinese super-SPF population at the California National Primate Research Center and in other primate facilities. Eastern Chinese rhesus appeared more highly derived than western Chinese rhesus, and allele sharing between longtails and Chinese rhesus was not random with regard to geographic distance, but no significant nuclear genetic differences between eastern and western Chinese rhesus were detected among the 245 genic SNPs assayed. Conclusion: The implications of this inter-specific admixture for the use of Chinese rhesus and mainland longtail in biomedical research should be considered.

KW - Genetic admixture

KW - Macaca fascicularis

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KW - Phylogenetics

KW - Population genetics

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