@article{42e2b28d4d314cc49c8d78e0e7351cf5,
title = "Design, synthesis, biochemical, and biological evaluation of nitrogen-containing trifluoro structural modifications of combretastatin A-4",
abstract = "A new trifluorinated amino-combretastatin analogue, (Z)-2-(4′-methoxy-3′-aminophenyl)-1-(3,4,5-trifluorophenyl)ethene, prepared by chemical synthesis, was found to be a potent inhibitor of tubulin assembly (IC50 = 2.9 μM), and cytotoxic against selected human cancer cell lines. This new lead compound is among the most active from a group of related structural modifications.",
keywords = "Anti-cancer agents, Combretastatin, Inhibitors of tubulin assembly",
author = "Hall, {John J.} and Madhavi Sriram and Strecker, {Tracy E.} and Tidmore, {Justin K.} and Jelinek, {Christopher J.} and Kumar, {G. D Kishore} and Hadimani, {Mallinath B.} and George Pettit and Chaplin, {David J.} and Trawick, {Mary Lynn} and Pinney, {Kevin G.}",
note = "Funding Information: The authors are grateful to Oxigene Inc. (Waltham, MA, grants to M.L.T. and K.G.P.) and The Welch Foundation (Grant AA-1278 to K.G.P.) for generous financial support of this research, and the National Science Foundation for funding both the Varian 500 MHz NMR spectrometer (Award CHE-0420802) and the Bruker X8 APEX diffractometer (Grant CHE-0321214). The authors are grateful to Prof. Charles M. Garner, and Mr. Cody Carson, graduate student, Department of Chemistry and Biochemistry, Baylor University, for assisting with structural analysis of selected compounds. The authors thank Dr. Alejandro Ramirez (Mass Spectrometry Core Facility, Baylor University) for HRMS analysis. The authors also thank H&B Packing (Waco, TX) for providing calf brain. ",
year = "2008",
month = sep,
day = "15",
doi = "10.1016/j.bmcl.2008.07.070",
language = "English (US)",
volume = "18",
pages = "5146--5149",
journal = "Bioorganic and Medicinal Chemistry Letters",
issn = "0960-894X",
publisher = "Elsevier Limited",
number = "18",
}