Design and synthesis of a potent phorboxazole C(11-15) acetal analogue

Amos B. Smith, Thomas M. Razler, Regina M. Meis, George Pettit

Research output: Contribution to journalArticle

23 Scopus citations

Abstract

We disclose here the design, synthesis, and biological evaluation of simplified Z- and E-C(2-3) alkynyl phorboxazole C(11-15) acetals (+)-7Z and (+)-7E, wherein the Z-isomer proved to be a potent nanomolar cytotoxic agent. Reevaluation of (+)-C(45-46) E-chloroalkenyl phorboxazole A (6) confirms subnanomolar activity across a broad panel of human cancer cell lines.

Original languageEnglish (US)
Pages (from-to)797-799
Number of pages3
JournalOrganic Letters
Volume8
Issue number4
DOIs
StatePublished - Feb 16 2006

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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