Design and synthesis of a potent phorboxazole C(11-15) acetal analogue

Amos B. Smith, Thomas M. Razler, Regina M. Meis, George Pettit

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

We disclose here the design, synthesis, and biological evaluation of simplified Z- and E-C(2-3) alkynyl phorboxazole C(11-15) acetals (+)-7Z and (+)-7E, wherein the Z-isomer proved to be a potent nanomolar cytotoxic agent. Reevaluation of (+)-C(45-46) E-chloroalkenyl phorboxazole A (6) confirms subnanomolar activity across a broad panel of human cancer cell lines.

Original languageEnglish (US)
Pages (from-to)797-799
Number of pages3
JournalOrganic Letters
Volume8
Issue number4
DOIs
StatePublished - Feb 16 2006

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acetals
Acetals
Cytotoxins
cultured cells
Isomers
isomers
cancer
Cells
analogs
Cell Line
evaluation
synthesis
Neoplasms
phorboxazole A

ASJC Scopus subject areas

  • Molecular Medicine

Cite this

Design and synthesis of a potent phorboxazole C(11-15) acetal analogue. / Smith, Amos B.; Razler, Thomas M.; Meis, Regina M.; Pettit, George.

In: Organic Letters, Vol. 8, No. 4, 16.02.2006, p. 797-799.

Research output: Contribution to journalArticle

Smith, Amos B. ; Razler, Thomas M. ; Meis, Regina M. ; Pettit, George. / Design and synthesis of a potent phorboxazole C(11-15) acetal analogue. In: Organic Letters. 2006 ; Vol. 8, No. 4. pp. 797-799.
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