Demonstration of a tumor-associated surface antigen in Marek's disease.

R. L. Witter, E. A. Stephens, J. M. Sharma, K. Nazerian

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77 Scopus citations

Abstract

Surface antigenic markers were detected on three classes of Marek's disease (MD) tumor cells, i.e., MD lymphoma cells, cultured cells of the MSB-1 lymphoblastoid cell line, and JMV lymphoblastic leukemia cells, by indirect membrane immunofluorescent staining with serum from chickens immunized with JMV cells or from rabbits immunized with MSB-1 cells. This surface antigen was not detected on normal chicken lymphocytes, RPL-16 tumor cells (tranedormed by an avian RNA virus, or MD virus-infected fibroblasts that were positive for viral membrane antigen (MA). Furthermore, the surface antigen appeared unrelated to embryonic or histocompatibility antigens. This antigen is provisionally designated as a Marek's disease tumor-associated surface antigen (MATSA). The MATSA's on JMV, MSB-1 and MD lymphoma cells were related but not identical as demonstrated by antiserum titration, absorption and blocking tests with homologous and heterologous systems.

Original languageEnglish (US)
Pages (from-to)177-183
Number of pages7
JournalJournal of Immunology
Volume115
Issue number1
StatePublished - Jul 1 1975

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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    Witter, R. L., Stephens, E. A., Sharma, J. M., & Nazerian, K. (1975). Demonstration of a tumor-associated surface antigen in Marek's disease. Journal of Immunology, 115(1), 177-183.