Delivery of plasmid DNA to mammalian cells using polymer-gold nanorod assemblies

James Ramos, Huang Chiao Huang, Kaushal Rege

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Scopus citations

Abstract

Functionalized and surface-modified gold nanorods (GNRs) have emerged as promising vehicles for the delivery of several therapeutic agents. Ease of functionalization, increased stability, biocompatibility, and size-dependent plasmonic properties make gold nanorods attractive in sensing, imaging, and delivery to different cellular types. Here, we demonstrate the use of polyelectrolyte-coated GNRs (PE-GNRs) for delivering plasmid DNA to mammalian cells for transgene expression.

Original languageEnglish (US)
Title of host publicationCellular and Subcellular Nanotechnology
Subtitle of host publicationMethods and Protocols
EditorsVolkmar Weissig, Mark Olsen, Tamer Elbayoumi
Pages81-91
Number of pages11
DOIs
StatePublished - 2013

Publication series

NameMethods in Molecular Biology
Volume991
ISSN (Print)1064-3745

Keywords

  • Cationic polymers
  • Gold nanoparticle
  • Nonviral gene delivery
  • Polyelectrolytes
  • Stability

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

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