Deglycobleomycin: Solid-Phase Synthesis and DNA Cleavage by the Resin-Bound Ligand

Kenneth L. Smith, Zhi Fu Tao, Shigeki Hashimoto, Christopher J. Leitheiser, Xihan Wu, Sidney M. Hecht

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

matrix presented A greatly improved solid-phase synthesis of deglycobleomycin using a Dde-based linker is reported. The resin-bound deglycobleomycin could be completely deblocked and assayed for DNA plasmid relaxation, sequence-selective DNA cleavage, and light production from a molecular beacon.

Original languageEnglish (US)
Pages (from-to)1079-1082
Number of pages4
JournalOrganic Letters
Volume4
Issue number7
DOIs
StatePublished - Apr 4 2002
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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