Deglycobleomycin: Solid-Phase Synthesis and DNA Cleavage by the Resin-Bound Ligand

Kenneth L. Smith; Zhi Fu Tao; Shigeki Hashimoto; Christopher J. Leitheiser; Xihan Wu; Sidney M. Hecht

doi:10.1021/ol010293g

Deglycobleomycin: Solid-Phase Synthesis and DNA Cleavage by the Resin-Bound Ligand

Kenneth L. Smith, Zhi Fu Tao, Shigeki Hashimoto, Christopher J. Leitheiser, Xihan Wu, Sidney M. Hecht

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

matrix presented A greatly improved solid-phase synthesis of deglycobleomycin using a Dde-based linker is reported. The resin-bound deglycobleomycin could be completely deblocked and assayed for DNA plasmid relaxation, sequence-selective DNA cleavage, and light production from a molecular beacon.

Original language	English (US)
Pages (from-to)	1079-1082
Number of pages	4
Journal	Organic Letters
Volume	4
Issue number	7
DOIs	https://doi.org/10.1021/ol010293g
State	Published - Apr 4 2002
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1021/ol010293g

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title = "Deglycobleomycin: Solid-Phase Synthesis and DNA Cleavage by the Resin-Bound Ligand",

abstract = "matrix presented A greatly improved solid-phase synthesis of deglycobleomycin using a Dde-based linker is reported. The resin-bound deglycobleomycin could be completely deblocked and assayed for DNA plasmid relaxation, sequence-selective DNA cleavage, and light production from a molecular beacon.",

author = "Smith, {Kenneth L.} and Tao, {Zhi Fu} and Shigeki Hashimoto and Leitheiser, {Christopher J.} and Xihan Wu and Hecht, {Sidney M.}",

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TY - JOUR

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T2 - Solid-Phase Synthesis and DNA Cleavage by the Resin-Bound Ligand

AU - Smith, Kenneth L.

AU - Tao, Zhi Fu

AU - Hashimoto, Shigeki

AU - Leitheiser, Christopher J.

AU - Wu, Xihan

AU - Hecht, Sidney M.

PY - 2002/4/4

Y1 - 2002/4/4

N2 - matrix presented A greatly improved solid-phase synthesis of deglycobleomycin using a Dde-based linker is reported. The resin-bound deglycobleomycin could be completely deblocked and assayed for DNA plasmid relaxation, sequence-selective DNA cleavage, and light production from a molecular beacon.

AB - matrix presented A greatly improved solid-phase synthesis of deglycobleomycin using a Dde-based linker is reported. The resin-bound deglycobleomycin could be completely deblocked and assayed for DNA plasmid relaxation, sequence-selective DNA cleavage, and light production from a molecular beacon.

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Deglycobleomycin: Solid-Phase Synthesis and DNA Cleavage by the Resin-Bound Ligand

Abstract

ASJC Scopus subject areas

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