TY - JOUR
T1 - Deep brain stimulation and cognitive outcomes among patients with Parkinson’s disease
T2 - A historical cohort study
AU - Hansen, Allison L.
AU - Krell-Roesch, Janina
AU - Kirlin, Kristin A.
AU - Limback-Stokin, Martin M.
AU - Roesler, Kimberly
AU - Velgos, Stefanie N.
AU - Lyons, Mark K.
AU - Geda, Yonas E.
AU - Mehta, Shyamal H.
N1 - Funding Information:
Supported by grants from NIH/National Institute on Aging (grant R01 AG057708) to Dr. Geda, the Robert Wood Johnson Foundation (to Dr. Geda), the Edli Foundation (to Dr. Geda), the Research Education Component of Arizona Alzheimer’s Disease Core Center (grant P30AG19610) to Dr. Geda, and the Arizona Alzheimer’s Consortium (to Dr. Geda).
Publisher Copyright:
© 2019, American Psychiatric Association. All rights reserved.
PY - 2019/7
Y1 - 2019/7
N2 - Objective: Deep brain stimulation (DBS) is an effective treatment for motor symptoms of Parkinson’s disease; however, there is conflicting literature about the effect of DBS on cognitive function. The authors conducted a historical cohort study involving patients with Parkinson’s disease who underwent DBS of the globus pallidus pars interna (GPi; N=12) or subthalamic nucleus (STN; N=17). Methods: The authors i nvesti gated di fferences i n four neuropsychol ogi cal test scores at 6 months post-DBS (follow-up) as compared with baseline (i.e., Boston Naming Test, WAIS Verbal Comprehension Index [WAIS-VCI], Working Memory Index [WAIS-WMI], and Processing Speed Index [WAIS-PSI]). Results: GPi DBS patients showed no difference between baseline and follow-up on any neuropsychological test. STN DBS patients had lower scores indicating decreased performance at follow-up as compared with baseline on WAIS-PSI (mean [SD], 91.47 [10.42] versus 81.65 [12.03]; p=0.03). There was a significant (p=0.008) difference between the change in baseline to follow-up scores on the WAIS-VCI for the STN DBS and GPi DBS groups (i.e., STN DBS patients scored lower at the 6-month follow-up compared with baseline, whereas GPi DBS patients scored higher). Conclusions: GPi may be a preferred target for DBS in patients with Parkinson’s disease when considering cognitive outcomes.
AB - Objective: Deep brain stimulation (DBS) is an effective treatment for motor symptoms of Parkinson’s disease; however, there is conflicting literature about the effect of DBS on cognitive function. The authors conducted a historical cohort study involving patients with Parkinson’s disease who underwent DBS of the globus pallidus pars interna (GPi; N=12) or subthalamic nucleus (STN; N=17). Methods: The authors i nvesti gated di fferences i n four neuropsychol ogi cal test scores at 6 months post-DBS (follow-up) as compared with baseline (i.e., Boston Naming Test, WAIS Verbal Comprehension Index [WAIS-VCI], Working Memory Index [WAIS-WMI], and Processing Speed Index [WAIS-PSI]). Results: GPi DBS patients showed no difference between baseline and follow-up on any neuropsychological test. STN DBS patients had lower scores indicating decreased performance at follow-up as compared with baseline on WAIS-PSI (mean [SD], 91.47 [10.42] versus 81.65 [12.03]; p=0.03). There was a significant (p=0.008) difference between the change in baseline to follow-up scores on the WAIS-VCI for the STN DBS and GPi DBS groups (i.e., STN DBS patients scored lower at the 6-month follow-up compared with baseline, whereas GPi DBS patients scored higher). Conclusions: GPi may be a preferred target for DBS in patients with Parkinson’s disease when considering cognitive outcomes.
UR - http://www.scopus.com/inward/record.url?scp=85073397261&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85073397261&partnerID=8YFLogxK
U2 - 10.1176/appi.neuropsych.18050118
DO - 10.1176/appi.neuropsych.18050118
M3 - Article
C2 - 30791806
AN - SCOPUS:85073397261
SN - 0895-0172
VL - 31
SP - 196
EP - 200
JO - Journal of Neuropsychiatry and Clinical Neurosciences
JF - Journal of Neuropsychiatry and Clinical Neurosciences
IS - 3
ER -