Decreased trkA gene expression within basal forebrain neurons in Alzheimer's disease

Elliott J. Mufson, J. M. Li, T. Sobreviela, J. H. Kordower

Research output: Contribution to journalArticlepeer-review

86 Scopus citations

Abstract

In situ hybridization for TrkA mRNA was combined with quantitative optical densitometry to evaluate whether the expression of this gene is altered within cholinergic basal forebrain neurons (CBF) in Alzheimer's disease (AD). TrkA mRNA within individual nucleus basalis neurons was significantly reduced (66%) in AD cases relative to aged controls. Reverse transcription polymerase chain reaction quantitative analyses confirmed that TrkA mRNA levels decreased markedly in AD. In contrast, expression of the gene coding for the low affinity p75(NTR) was not significantly altered in AD relative to aged controls. These data indicate that there is a selective defect in trkA gene expression in AD, supporting the hypothesis that the degeneration of CBF neurons seen in this disease results from impaired nerve growth factor trophic support.

Original languageEnglish (US)
Pages (from-to)25-29
Number of pages5
JournalNeuroReport
Volume8
Issue number1
DOIs
StatePublished - 1997
Externally publishedYes

Keywords

  • Ageing
  • Disease
  • Gene
  • Human
  • In situ hybridization
  • Receptors
  • TrkA

ASJC Scopus subject areas

  • Neuroscience(all)

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