Decarboxylative trifluoromethylation of aryl halides using well-defined copper-trifluoroacetate and -chlorodifluoroacetate precursors

Kristen A. McReynolds, Robert S. Lewis, Laura K.G. Ackerman, Galyna G. Dubinina, William W. Brennessel, David A. Vicic

Research output: Contribution to journalArticlepeer-review

74 Scopus citations

Abstract

New synthetic routes to (NHC)copper-trifluoroacetate and -chlorodifluoroacetate complexes were developed (NHC = N-heterocyclic carbenes) so baseline reactivity patterns could be established for the decarboxylative trifluoromethylation of organic halides. In the presence of aryl halides, loss of CO2 from these new precursors occurred at 160 °C concurrent with the formation of aryl-CF3.

Original languageEnglish (US)
Pages (from-to)1108-1112
Number of pages5
JournalJournal of Fluorine Chemistry
Volume131
Issue number11
DOIs
StatePublished - Nov 2010
Externally publishedYes

Keywords

  • Copper
  • Organometallic
  • Trifluoromethylation

ASJC Scopus subject areas

  • Biochemistry
  • Environmental Chemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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