@article{a69af111df0b4db5a08f22d525a459e5,
title = "Decarboxylative Cross-Electrophile Coupling of N-Hydroxyphthalimide Esters with Aryl Iodides",
abstract = "A new method for the decarboxylative coupling of alkyl N-hydroxyphthalimide esters (NHP esters) with aryl iodides is presented. In contrast to previous studies that form alkyl radicals from carboxylic acid derivatives, no photocatalyst, light, or arylmetal reagent is needed, only nickel and a reducing agent (Zn). Methyl, primary, and secondary alkyl groups can all be coupled in good yield (77% ave yield). One coupling with an acid chloride is also presented. Stoichiometric reactions of (dtbbpy)Ni(2-tolyl)I with an NHP ester show for the first time that arylnickel(II) complexes can directly react with NHP esters to form alkylated arenes.",
author = "Huihui, {Kierra M.M.} and Caputo, {Jill A.} and Zulema Melchor and Olivares, {Astrid M.} and Spiewak, {Amanda M.} and Johnson, {Keywan A.} and Dibenedetto, {Tarah A.} and Seoyoung Kim and Ackerman, {Laura K.G.} and Weix, {Daniel J.}",
note = "Funding Information: The authors gratefully acknowledge funding from the NIH NIGMS (R01 GM097243). L.K.G.A. acknowledges funding from the University of Rochester (Elon Huntington Hooker Fellowship). K.A.J. acknowledges funding from an NSF GRFP award (DGE-1419118). D.J.W. is a Camille Dreyfus Teacher-Scholar. Additional funding from Novartis, Pfizer, and Boehringer Ingelheim is also gratefully acknowledged. Analytical data were obtained from the CENTC Elemental Analysis Facility at the University of Rochester, funded by NSF CHE-0650456. Prof. Larry Overman is thanked for suggesting that we look at NHP esters for cross-electrophile coupling.",
year = "2016",
month = may,
day = "4",
doi = "10.1021/jacs.6b01533",
language = "English (US)",
volume = "138",
pages = "5016--5019",
journal = "Journal of the American Chemical Society",
issn = "0002-7863",
publisher = "American Chemical Society",
number = "15",
}