The interior of the cell: A complex solvent. Biochemical reactions under physiological and extreme conditions

Matthias Heyden, Simon Ebbinghaus, Roland Winter

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

The interior of a living cell is very distinct from dilute aqueous solutions that are often used to study the function of proteins and enzymes experimentally. Here, we discuss novel experimental techniques and modeling approaches that provide a deeper understanding of the effects of crowding, intermolecular interactions, and the influence of osmolytes in realistic biological environments, including cells. Further, we discuss adaptation mechanisms involving in-cell solvation environments to extreme conditions, such as high pressure in the deep sea, and their relevance to biotechnology.

Original languageEnglish (US)
Pages (from-to)26-33
Number of pages8
JournalChemie in Unserer Zeit
Volume51
Issue number1
DOIs
StatePublished - Feb 1 2017
Externally publishedYes

ASJC Scopus subject areas

  • General Chemistry

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