Cytotoxic naphthoquinones, molluscicidal saponins and flavonols from Diospyros zombensis

Frank Gafner; Jean Charles Chapuis; Jerome D. Msonthi; Kurt Hostettmann

doi:10.1016/S0031-9422(00)83864-9

Cytotoxic naphthoquinones, molluscicidal saponins and flavonols from Diospyros zombensis

Frank Gafner, Jean Charles Chapuis, Jerome D. Msonthi, Kurt Hostettmann

Arizona State University

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

7-Methyljuglone, isodiospyrin and three glucuronides of oleanolic acid were isolated from the lipophilic and the methanol extracts, respectively, of the root bark of Diospyros zombensis. Cytotoxic activities of the naphthoquinones and strong molluscicidal activity of 3-O-[O-α-L-rhamnopyranosyl-(1 → 3)-β-D-glucuronopyranosyl]-oleanolic acid were shown. In addition hyperoside, quercitrin and quercetin-3-O-β-D-glucuronopyranoside were isolated from a methanol extract of the leaves.

Original language	English (US)
Pages (from-to)	2501-2503
Number of pages	3
Journal	Phytochemistry
Volume	26
Issue number	9
DOIs	https://doi.org/10.1016/S0031-9422(00)83864-9
State	Published - 1987

Keywords

Diospyros zombensis
Ebenaceae
cytotoxins.
flavone glycosides
molluscicides
naphthoquinones
saponins

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Plant Science
Horticulture

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10.1016/S0031-9422(00)83864-9

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@article{89b1a77df070416f9deb0d64345c4eb1,

title = "Cytotoxic naphthoquinones, molluscicidal saponins and flavonols from Diospyros zombensis",

abstract = "7-Methyljuglone, isodiospyrin and three glucuronides of oleanolic acid were isolated from the lipophilic and the methanol extracts, respectively, of the root bark of Diospyros zombensis. Cytotoxic activities of the naphthoquinones and strong molluscicidal activity of 3-O-[O-α-L-rhamnopyranosyl-(1 → 3)-β-D-glucuronopyranosyl]-oleanolic acid were shown. In addition hyperoside, quercitrin and quercetin-3-O-β-D-glucuronopyranoside were isolated from a methanol extract of the leaves.",

keywords = "Diospyros zombensis, Ebenaceae, cytotoxins., flavone glycosides, molluscicides, naphthoquinones, saponins",

author = "Frank Gafner and Chapuis, {Jean Charles} and {D. Msonthi}, Jerome and Kurt Hostettmann",

note = "Funding Information: Acknowledgements-Financial support has been provided by the UNDP/World Bank/WHO Special Programme for Research and Training in Tropical Diseases and by the Swiss National Science Foundation. Thanks are also due to G. Dudan for carrying out the bioassays.",

year = "1987",

doi = "10.1016/S0031-9422(00)83864-9",

language = "English (US)",

volume = "26",

pages = "2501--2503",

journal = "Phytochemistry",

issn = "0031-9422",

publisher = "Elsevier Limited",

number = "9",

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TY - JOUR

T1 - Cytotoxic naphthoquinones, molluscicidal saponins and flavonols from Diospyros zombensis

AU - Gafner, Frank

AU - Chapuis, Jean Charles

AU - D. Msonthi, Jerome

AU - Hostettmann, Kurt

N1 - Funding Information: Acknowledgements-Financial support has been provided by the UNDP/World Bank/WHO Special Programme for Research and Training in Tropical Diseases and by the Swiss National Science Foundation. Thanks are also due to G. Dudan for carrying out the bioassays.

PY - 1987

Y1 - 1987

N2 - 7-Methyljuglone, isodiospyrin and three glucuronides of oleanolic acid were isolated from the lipophilic and the methanol extracts, respectively, of the root bark of Diospyros zombensis. Cytotoxic activities of the naphthoquinones and strong molluscicidal activity of 3-O-[O-α-L-rhamnopyranosyl-(1 → 3)-β-D-glucuronopyranosyl]-oleanolic acid were shown. In addition hyperoside, quercitrin and quercetin-3-O-β-D-glucuronopyranoside were isolated from a methanol extract of the leaves.

AB - 7-Methyljuglone, isodiospyrin and three glucuronides of oleanolic acid were isolated from the lipophilic and the methanol extracts, respectively, of the root bark of Diospyros zombensis. Cytotoxic activities of the naphthoquinones and strong molluscicidal activity of 3-O-[O-α-L-rhamnopyranosyl-(1 → 3)-β-D-glucuronopyranosyl]-oleanolic acid were shown. In addition hyperoside, quercitrin and quercetin-3-O-β-D-glucuronopyranoside were isolated from a methanol extract of the leaves.

KW - Diospyros zombensis

KW - Ebenaceae

KW - cytotoxins.

KW - flavone glycosides

KW - molluscicides

KW - naphthoquinones

KW - saponins

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U2 - 10.1016/S0031-9422(00)83864-9

DO - 10.1016/S0031-9422(00)83864-9

M3 - Article

AN - SCOPUS:0007640329

VL - 26

SP - 2501

EP - 2503

JO - Phytochemistry

JF - Phytochemistry

SN - 0031-9422

IS - 9

ER -

Cytotoxic naphthoquinones, molluscicidal saponins and flavonols from Diospyros zombensis

Abstract

Keywords

ASJC Scopus subject areas

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