Cytotoxic lipid esters from Peucedanum ledebourielloides

Xing Zheng, Jiang Du, Yunlong Xu, Duanfang Liao, George Pettit

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Two cancer cell growth inhibitory esters, 1,2-dipalmitoyl-3-glucosyl glycerol (1) and 1,6-dihydroxy-hexane-bis-palmitoyl ester (2), together with arachidic acid-2-hydroxy-glycerol ester, daucosterol, and oleanolic acid, were isolated from the roots of Peucedanum ledebourielloides (Apiaceae family). The structures were determined by spectroscopic analyses. The esters 1 and 2 displayed significant activity against the SGC-7901, HT-29, and HL-60 cancer cell lines.

Original languageEnglish (US)
Pages (from-to)337-343
Number of pages7
JournalMedicinal Chemistry Research
Volume19
Issue number4
DOIs
Publication statusPublished - May 2010

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Keywords

  • Anticancer
  • Apiaceae family
  • Ester
  • Peucedanum ledebourielloides

ASJC Scopus subject areas

  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Organic Chemistry

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