TY - JOUR
T1 - Cytotoxic lipid esters from Peucedanum ledebourielloides
AU - Zheng, Xing
AU - Du, Jiang
AU - Xu, Yunlong
AU - Liao, Duanfang
AU - Pettit, George
N1 - Funding Information:
Acknowledgement The authors thank the Department of Education of Hunan (07B065) and the Department Science and Technology of Hunan (2007FJ4155) for financial support. Special thanks are due to the Analytical Center, State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany of Chinese Academy of Sciences, for recording IR, MS, and NMR spectra. The authors also thank Prof. Langran Xu for plant identification. Two authors (GRP and JD) are pleased to acknowledge the financial support of CA90441-5 and CA90441-06A1 awarded by the Division of Cancer Treatment and Diagnosis, National Cancer Institute, DHHS, the Arizona Biomedical Research Commission, and the assistance of Professor Fiona Hogan.
PY - 2010/5
Y1 - 2010/5
N2 - Two cancer cell growth inhibitory esters, 1,2-dipalmitoyl-3-glucosyl glycerol (1) and 1,6-dihydroxy-hexane-bis-palmitoyl ester (2), together with arachidic acid-2-hydroxy-glycerol ester, daucosterol, and oleanolic acid, were isolated from the roots of Peucedanum ledebourielloides (Apiaceae family). The structures were determined by spectroscopic analyses. The esters 1 and 2 displayed significant activity against the SGC-7901, HT-29, and HL-60 cancer cell lines.
AB - Two cancer cell growth inhibitory esters, 1,2-dipalmitoyl-3-glucosyl glycerol (1) and 1,6-dihydroxy-hexane-bis-palmitoyl ester (2), together with arachidic acid-2-hydroxy-glycerol ester, daucosterol, and oleanolic acid, were isolated from the roots of Peucedanum ledebourielloides (Apiaceae family). The structures were determined by spectroscopic analyses. The esters 1 and 2 displayed significant activity against the SGC-7901, HT-29, and HL-60 cancer cell lines.
KW - Anticancer
KW - Apiaceae family
KW - Ester
KW - Peucedanum ledebourielloides
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U2 - 10.1007/s00044-009-9193-9
DO - 10.1007/s00044-009-9193-9
M3 - Article
AN - SCOPUS:77954083940
SN - 1054-2523
VL - 19
SP - 337
EP - 343
JO - Medicinal Chemistry Research
JF - Medicinal Chemistry Research
IS - 4
ER -