Cytokine Receptors in the Brain

Bruno Conti, Iustin Tabarean, Manuel Sanchez-Alavez, Christopher Davis, Sara Brownell, Margarita Behrens, Tamas Bartfai

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Cytokines, once thought to be specialized molecules of the immune system, are now being investigated also for their synaptic and inflammatory action on the central nervous system (CNS). These proteins and their receptors can be synthesized in the brain by glial and neuronal cells and contribute to two main types of action: modulation of neuronal excitability and local inflammatory responses. We present an overview of the distribution, regulation, and function of neuronal cytokine receptors in the CNS, specifically focusing on the interleukin-1 receptor (IL-1R), tumor necrosis factor receptor (TNFR), interleukin-6 receptor (IL-6R), and interleukin-10 receptor (IL-10R), because their ligands are the most studied pro- and anti-inflammatory cytokines in the brain.

Original languageEnglish (US)
JournalNeuroImmune Biology
Volume6
Issue numberC
DOIs
StatePublished - 2007
Externally publishedYes

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Cytokine Receptors
Interleukin-10 Receptors
Central Nervous System
Cytokines
Interleukin-6 Receptors
Interleukin-1 Receptors
Tumor Necrosis Factor Receptors
Brain
Neuroglia
Immune System
Anti-Inflammatory Agents
Ligands
Proteins

ASJC Scopus subject areas

  • Immunology
  • Clinical Neurology
  • Neurology

Cite this

Conti, B., Tabarean, I., Sanchez-Alavez, M., Davis, C., Brownell, S., Behrens, M., & Bartfai, T. (2007). Cytokine Receptors in the Brain. NeuroImmune Biology, 6(C). https://doi.org/10.1016/S1567-7443(07)10002-8

Cytokine Receptors in the Brain. / Conti, Bruno; Tabarean, Iustin; Sanchez-Alavez, Manuel; Davis, Christopher; Brownell, Sara; Behrens, Margarita; Bartfai, Tamas.

In: NeuroImmune Biology, Vol. 6, No. C, 2007.

Research output: Contribution to journalArticle

Conti, B, Tabarean, I, Sanchez-Alavez, M, Davis, C, Brownell, S, Behrens, M & Bartfai, T 2007, 'Cytokine Receptors in the Brain', NeuroImmune Biology, vol. 6, no. C. https://doi.org/10.1016/S1567-7443(07)10002-8
Conti B, Tabarean I, Sanchez-Alavez M, Davis C, Brownell S, Behrens M et al. Cytokine Receptors in the Brain. NeuroImmune Biology. 2007;6(C). https://doi.org/10.1016/S1567-7443(07)10002-8
Conti, Bruno ; Tabarean, Iustin ; Sanchez-Alavez, Manuel ; Davis, Christopher ; Brownell, Sara ; Behrens, Margarita ; Bartfai, Tamas. / Cytokine Receptors in the Brain. In: NeuroImmune Biology. 2007 ; Vol. 6, No. C.
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