Cytokines, once thought to be specialized molecules of the immune system, are now being investigated also for their synaptic and inflammatory action on the central nervous system (CNS). These proteins and their receptors can be synthesized in the brain by glial and neuronal cells and contribute to two main types of action: modulation of neuronal excitability and local inflammatory responses. We present an overview of the distribution, regulation, and function of neuronal cytokine receptors in the CNS, specifically focusing on the interleukin-1 receptor (IL-1R), tumor necrosis factor receptor (TNFR), interleukin-6 receptor (IL-6R), and interleukin-10 receptor (IL-10R), because their ligands are the most studied pro- and anti-inflammatory cytokines in the brain.
ASJC Scopus subject areas
- Clinical Neurology