Cytokine gene polymorphisms are associated with susceptibility to tuberculosis in an Amerindian population

J. D. Lindenau, L. S P Guimarães, D. C. Friedrich, Ana Hurtado, Kim Hill, F. M. Salzano, Mara H. Hutz

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

SETTING: Cytokines play an important role in antituberculosis immune response, combined with antigen-presenting cells and lymphocytes. Immune response gene polymorphisms have been reported to be associated with tuberculosis (TB) susceptibility in some but not all studies. OBJECTIVE: To evaluate the association of immune response genes with susceptibility to tuberculin skin test (TST) reactivity and/or TB. DESIGN: Fourteen single nucleotide polymorphisms were genotyped in 96 individuals of the Aché, a native Paraguayan population, by allelic discrimination using real-time polymerase chain reaction. Univariate and multivariate Poisson regression were employed to assess risk genotypes. RESULTS: A higher prevalence of purified protein derivative reactivity was associated with the TNF-α CCA/TCG haplotype (PR 1.298, 95%CI 1.059-1.589) and with the IL-10 AT/CC diplotype (PR 1.181, 95% CI 1.024-1.362), and the presence of the IL-8 rs4073 T allele was associated with protection against TB (PR 0.482, 95%CI 0.273-0.851). CONCLUSIONS: These results suggest that polymorphisms in genes associated with immune response are involved in TSTreactivity and susceptibility to TB in the Aché population.

Original languageEnglish (US)
Pages (from-to)952-957
Number of pages6
JournalInternational Journal of Tuberculosis and Lung Disease
Volume18
Issue number8
DOIs
StatePublished - Aug 1 2014

Keywords

  • Anergy
  • Infectious diseases
  • Interleukins
  • Native Americans

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Infectious Diseases

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