Cytokine determinants of viral tropism

Douglas McFadden, Mohamed R. Mohamed, Masmudur Rahman, Eric Bartee

Research output: Contribution to journalReview article

54 Citations (Scopus)

Abstract

The specificity of a given virus for a cell type, tissue or species collectively known as viral tropism is an important factor in determining the outcome of viral infection in any particular host. Owing to the increased prevalence of zoonotic infections and the threat of emerging and re-emerging pathogens, gaining a better understanding of the factors that determine viral tropism has become particularly important. In this Review, we summarize our current understanding of the central role of antiviral and pro-inflammatory cytokines, particularly the interferons and tumour necrosis factor, in dictating viral tropism and how these cytokine pathways can be exploited therapeutically for cancer treatment and to better counter future threats from emerging zoonotic pathogens.

Original languageEnglish (US)
Pages (from-to)645-655
Number of pages11
JournalNature Reviews Immunology
Volume9
Issue number9
DOIs
StatePublished - Sep 1 2009
Externally publishedYes

Fingerprint

Viral Tropism
Zoonoses
Cytokines
Virus Diseases
Interferons
Antiviral Agents
Tumor Necrosis Factor-alpha
Viruses
Neoplasms

ASJC Scopus subject areas

  • Immunology

Cite this

Cytokine determinants of viral tropism. / McFadden, Douglas; Mohamed, Mohamed R.; Rahman, Masmudur; Bartee, Eric.

In: Nature Reviews Immunology, Vol. 9, No. 9, 01.09.2009, p. 645-655.

Research output: Contribution to journalReview article

McFadden, Douglas ; Mohamed, Mohamed R. ; Rahman, Masmudur ; Bartee, Eric. / Cytokine determinants of viral tropism. In: Nature Reviews Immunology. 2009 ; Vol. 9, No. 9. pp. 645-655.
@article{b30a17601f5c42508c62e6e5a584f865,
title = "Cytokine determinants of viral tropism",
abstract = "The specificity of a given virus for a cell type, tissue or species collectively known as viral tropism is an important factor in determining the outcome of viral infection in any particular host. Owing to the increased prevalence of zoonotic infections and the threat of emerging and re-emerging pathogens, gaining a better understanding of the factors that determine viral tropism has become particularly important. In this Review, we summarize our current understanding of the central role of antiviral and pro-inflammatory cytokines, particularly the interferons and tumour necrosis factor, in dictating viral tropism and how these cytokine pathways can be exploited therapeutically for cancer treatment and to better counter future threats from emerging zoonotic pathogens.",
author = "Douglas McFadden and Mohamed, {Mohamed R.} and Masmudur Rahman and Eric Bartee",
year = "2009",
month = "9",
day = "1",
doi = "10.1038/nri2623",
language = "English (US)",
volume = "9",
pages = "645--655",
journal = "Nature Reviews Immunology",
issn = "1474-1733",
publisher = "Nature Publishing Group",
number = "9",

}

TY - JOUR

T1 - Cytokine determinants of viral tropism

AU - McFadden, Douglas

AU - Mohamed, Mohamed R.

AU - Rahman, Masmudur

AU - Bartee, Eric

PY - 2009/9/1

Y1 - 2009/9/1

N2 - The specificity of a given virus for a cell type, tissue or species collectively known as viral tropism is an important factor in determining the outcome of viral infection in any particular host. Owing to the increased prevalence of zoonotic infections and the threat of emerging and re-emerging pathogens, gaining a better understanding of the factors that determine viral tropism has become particularly important. In this Review, we summarize our current understanding of the central role of antiviral and pro-inflammatory cytokines, particularly the interferons and tumour necrosis factor, in dictating viral tropism and how these cytokine pathways can be exploited therapeutically for cancer treatment and to better counter future threats from emerging zoonotic pathogens.

AB - The specificity of a given virus for a cell type, tissue or species collectively known as viral tropism is an important factor in determining the outcome of viral infection in any particular host. Owing to the increased prevalence of zoonotic infections and the threat of emerging and re-emerging pathogens, gaining a better understanding of the factors that determine viral tropism has become particularly important. In this Review, we summarize our current understanding of the central role of antiviral and pro-inflammatory cytokines, particularly the interferons and tumour necrosis factor, in dictating viral tropism and how these cytokine pathways can be exploited therapeutically for cancer treatment and to better counter future threats from emerging zoonotic pathogens.

UR - http://www.scopus.com/inward/record.url?scp=70249134047&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=70249134047&partnerID=8YFLogxK

U2 - 10.1038/nri2623

DO - 10.1038/nri2623

M3 - Review article

VL - 9

SP - 645

EP - 655

JO - Nature Reviews Immunology

JF - Nature Reviews Immunology

SN - 1474-1733

IS - 9

ER -