Cyst fluid NB/70K concentration and leukocyte esterase: Two new markers for differentiating pancreatic serous tumors from pseudocysts

W. H. Yong, J. F. Southern, M. R. Pins, A. L. Warshaw, Carolyn Compton, K. B. Lewandrowski

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Cystic lesions of the pancreas include inflammatory pseudocysts, serous cystadenomas, and mucinous tumors, some of which are malignant. Preoperative clinical and radiological parameters are unreliable and may result in incorrect diagnosis and inappropriate treatment. Cyst fluid analysis for cytology, viscosity, carcinoembryonic antigen, CA 72-4, and CA 15-3 will distinguish mucinous from nonmucinous lesions and usually help in determining malignancy. Currently, there is no reliable method to differentiate inflammatory pseudocysts from serous cystadenomas. This distinction is important because the treatment of these two lesions is different; pseudocysts are either observed or drained, whereas serous tumors are usually resected. The tumor marker NB/70K was measured in aspirated cyst fluid from 13 inflammatory pseudocysts and 11 serous cystadenomas by a commercial immunoassay. Leukocyte esterase was measured using Chemstrip SG urine test strips and amylase and lipase on a routine chemistry analyzer. The cyst fluid NB/70K concentration was significantly higher in pseudocysts (mean, 555 U/ml; range, 42-1,926 U/ml) than in serous cystadenomas (mean, 12 U/ml; range, 0- 130 U/ml) and this difference was significant (p < 0.0002). Leukocyte esterase was detected in 7 of 11 pseudocysts but was absent in 10 of 10 serous tumors (p = 0.002). Amylase and lipase values were generally higher in pseudocysts but these markers were unreliable due to marked outliers. Cyst fluid NB/70K and leukocyte esterase are promising markers to help differentiate pseudocysts from serous tumors on percutaneous aspirates. When combined with previously reported cyst fluid parameters (amylase, lipase, cytology, and amylase isoenzymes), these two cystic lesions can be reliably distinguished.

Original languageEnglish (US)
Pages (from-to)342-346
Number of pages5
JournalPancreas
Volume10
Issue number4
StatePublished - 1995
Externally publishedYes

Fingerprint

Cyst Fluid
Serous Cystadenoma
Amylases
Lipase
Neoplasms
Cell Biology
Carcinoembryonic Antigen
Tumor Biomarkers
Immunoassay
Viscosity
Isoenzymes
Pancreas
leukocyte esterase
Urine
Therapeutics

Keywords

  • Cystic fluid NB/70K
  • Leukocyte esterase
  • Pseudocysts
  • Serous tumors

ASJC Scopus subject areas

  • Endocrinology
  • Gastroenterology

Cite this

Yong, W. H., Southern, J. F., Pins, M. R., Warshaw, A. L., Compton, C., & Lewandrowski, K. B. (1995). Cyst fluid NB/70K concentration and leukocyte esterase: Two new markers for differentiating pancreatic serous tumors from pseudocysts. Pancreas, 10(4), 342-346.

Cyst fluid NB/70K concentration and leukocyte esterase : Two new markers for differentiating pancreatic serous tumors from pseudocysts. / Yong, W. H.; Southern, J. F.; Pins, M. R.; Warshaw, A. L.; Compton, Carolyn; Lewandrowski, K. B.

In: Pancreas, Vol. 10, No. 4, 1995, p. 342-346.

Research output: Contribution to journalArticle

Yong, WH, Southern, JF, Pins, MR, Warshaw, AL, Compton, C & Lewandrowski, KB 1995, 'Cyst fluid NB/70K concentration and leukocyte esterase: Two new markers for differentiating pancreatic serous tumors from pseudocysts', Pancreas, vol. 10, no. 4, pp. 342-346.
Yong, W. H. ; Southern, J. F. ; Pins, M. R. ; Warshaw, A. L. ; Compton, Carolyn ; Lewandrowski, K. B. / Cyst fluid NB/70K concentration and leukocyte esterase : Two new markers for differentiating pancreatic serous tumors from pseudocysts. In: Pancreas. 1995 ; Vol. 10, No. 4. pp. 342-346.
@article{6a8ce6eb25774f8494291525ecf374fa,
title = "Cyst fluid NB/70K concentration and leukocyte esterase: Two new markers for differentiating pancreatic serous tumors from pseudocysts",
abstract = "Cystic lesions of the pancreas include inflammatory pseudocysts, serous cystadenomas, and mucinous tumors, some of which are malignant. Preoperative clinical and radiological parameters are unreliable and may result in incorrect diagnosis and inappropriate treatment. Cyst fluid analysis for cytology, viscosity, carcinoembryonic antigen, CA 72-4, and CA 15-3 will distinguish mucinous from nonmucinous lesions and usually help in determining malignancy. Currently, there is no reliable method to differentiate inflammatory pseudocysts from serous cystadenomas. This distinction is important because the treatment of these two lesions is different; pseudocysts are either observed or drained, whereas serous tumors are usually resected. The tumor marker NB/70K was measured in aspirated cyst fluid from 13 inflammatory pseudocysts and 11 serous cystadenomas by a commercial immunoassay. Leukocyte esterase was measured using Chemstrip SG urine test strips and amylase and lipase on a routine chemistry analyzer. The cyst fluid NB/70K concentration was significantly higher in pseudocysts (mean, 555 U/ml; range, 42-1,926 U/ml) than in serous cystadenomas (mean, 12 U/ml; range, 0- 130 U/ml) and this difference was significant (p < 0.0002). Leukocyte esterase was detected in 7 of 11 pseudocysts but was absent in 10 of 10 serous tumors (p = 0.002). Amylase and lipase values were generally higher in pseudocysts but these markers were unreliable due to marked outliers. Cyst fluid NB/70K and leukocyte esterase are promising markers to help differentiate pseudocysts from serous tumors on percutaneous aspirates. When combined with previously reported cyst fluid parameters (amylase, lipase, cytology, and amylase isoenzymes), these two cystic lesions can be reliably distinguished.",
keywords = "Cystic fluid NB/70K, Leukocyte esterase, Pseudocysts, Serous tumors",
author = "Yong, {W. H.} and Southern, {J. F.} and Pins, {M. R.} and Warshaw, {A. L.} and Carolyn Compton and Lewandrowski, {K. B.}",
year = "1995",
language = "English (US)",
volume = "10",
pages = "342--346",
journal = "Pancreas",
issn = "0885-3177",
publisher = "Lippincott Williams and Wilkins",
number = "4",

}

TY - JOUR

T1 - Cyst fluid NB/70K concentration and leukocyte esterase

T2 - Two new markers for differentiating pancreatic serous tumors from pseudocysts

AU - Yong, W. H.

AU - Southern, J. F.

AU - Pins, M. R.

AU - Warshaw, A. L.

AU - Compton, Carolyn

AU - Lewandrowski, K. B.

PY - 1995

Y1 - 1995

N2 - Cystic lesions of the pancreas include inflammatory pseudocysts, serous cystadenomas, and mucinous tumors, some of which are malignant. Preoperative clinical and radiological parameters are unreliable and may result in incorrect diagnosis and inappropriate treatment. Cyst fluid analysis for cytology, viscosity, carcinoembryonic antigen, CA 72-4, and CA 15-3 will distinguish mucinous from nonmucinous lesions and usually help in determining malignancy. Currently, there is no reliable method to differentiate inflammatory pseudocysts from serous cystadenomas. This distinction is important because the treatment of these two lesions is different; pseudocysts are either observed or drained, whereas serous tumors are usually resected. The tumor marker NB/70K was measured in aspirated cyst fluid from 13 inflammatory pseudocysts and 11 serous cystadenomas by a commercial immunoassay. Leukocyte esterase was measured using Chemstrip SG urine test strips and amylase and lipase on a routine chemistry analyzer. The cyst fluid NB/70K concentration was significantly higher in pseudocysts (mean, 555 U/ml; range, 42-1,926 U/ml) than in serous cystadenomas (mean, 12 U/ml; range, 0- 130 U/ml) and this difference was significant (p < 0.0002). Leukocyte esterase was detected in 7 of 11 pseudocysts but was absent in 10 of 10 serous tumors (p = 0.002). Amylase and lipase values were generally higher in pseudocysts but these markers were unreliable due to marked outliers. Cyst fluid NB/70K and leukocyte esterase are promising markers to help differentiate pseudocysts from serous tumors on percutaneous aspirates. When combined with previously reported cyst fluid parameters (amylase, lipase, cytology, and amylase isoenzymes), these two cystic lesions can be reliably distinguished.

AB - Cystic lesions of the pancreas include inflammatory pseudocysts, serous cystadenomas, and mucinous tumors, some of which are malignant. Preoperative clinical and radiological parameters are unreliable and may result in incorrect diagnosis and inappropriate treatment. Cyst fluid analysis for cytology, viscosity, carcinoembryonic antigen, CA 72-4, and CA 15-3 will distinguish mucinous from nonmucinous lesions and usually help in determining malignancy. Currently, there is no reliable method to differentiate inflammatory pseudocysts from serous cystadenomas. This distinction is important because the treatment of these two lesions is different; pseudocysts are either observed or drained, whereas serous tumors are usually resected. The tumor marker NB/70K was measured in aspirated cyst fluid from 13 inflammatory pseudocysts and 11 serous cystadenomas by a commercial immunoassay. Leukocyte esterase was measured using Chemstrip SG urine test strips and amylase and lipase on a routine chemistry analyzer. The cyst fluid NB/70K concentration was significantly higher in pseudocysts (mean, 555 U/ml; range, 42-1,926 U/ml) than in serous cystadenomas (mean, 12 U/ml; range, 0- 130 U/ml) and this difference was significant (p < 0.0002). Leukocyte esterase was detected in 7 of 11 pseudocysts but was absent in 10 of 10 serous tumors (p = 0.002). Amylase and lipase values were generally higher in pseudocysts but these markers were unreliable due to marked outliers. Cyst fluid NB/70K and leukocyte esterase are promising markers to help differentiate pseudocysts from serous tumors on percutaneous aspirates. When combined with previously reported cyst fluid parameters (amylase, lipase, cytology, and amylase isoenzymes), these two cystic lesions can be reliably distinguished.

KW - Cystic fluid NB/70K

KW - Leukocyte esterase

KW - Pseudocysts

KW - Serous tumors

UR - http://www.scopus.com/inward/record.url?scp=0028950729&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028950729&partnerID=8YFLogxK

M3 - Article

C2 - 7792290

AN - SCOPUS:0028950729

VL - 10

SP - 342

EP - 346

JO - Pancreas

JF - Pancreas

SN - 0885-3177

IS - 4

ER -