Abstract
Aminoacyl-tRNA (transfer RNA) synthetases are essential components of the cellular translation machinery as they provide the ribosome with aminoacyl-tRNAs. Aminoacyl-tRNA synthesis is generally well understood. However, the mechanism of Cys-tRNACys formation in three methanogenic archaea (Methanocaldococcus jannaschii, Methanothermobacter thermautotrophicus and Methanopyrus kandleri) is still unknown, since no recognizable gene for a canonical cysteinyl-tRNA synthetase could be identified in the genome sequences of these organisms. Here we review the different routes recently proposed for Cys-tRNACys formation and discuss its possible link with cysteine biosynthesis in these methanogenic archaea.
Original language | English (US) |
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Pages (from-to) | 2437-2445 |
Number of pages | 9 |
Journal | Cellular and Molecular Life Sciences |
Volume | 61 |
Issue number | 19-20 |
DOIs | |
State | Published - Oct 2004 |
Externally published | Yes |
Keywords
- Archaea
- Cys-tRNA
- Cysteine biosynthesis
- Cysteinyl-tRNA synthetase
- Methanogens
ASJC Scopus subject areas
- Molecular Medicine
- Molecular Biology
- Pharmacology
- Cellular and Molecular Neuroscience
- Cell Biology