Targetry and a radiochemical process are reported for the production of no-carrier-added (NCA) 101mRh for use in the synthesis of radiopharmaceuticals. Proton-induced reactions on 103Rh targets were studied in order to evaluate the 103Rh(p,3n)101Pd→101mRh reaction as a source of high radionuclidic purity 101mRh. Cross sections (mb) and thin-target yields (mCi/μAh) for 101mRh, 101Rh, 100Rh, 101Pd, and 100Pd were measured at end-of-bombardment (EOB). The theoretical 101mRh cumulative yield from its 101Pd parent, at 32.7 h post EOB, was calculated as 4.71 ± 0.61 mCi/μAh, in the 67-to 15-MeV energy region. However, due to the production of the 20.8-h 100Rh, from its parent 3.63-d 100Pd, in the same energy region, a long decay time (> 170 h) is required to increase the radionuclidic purity of 101mRh to greater than 99%. The "effective" 101mRh yield is then reduced (to 1.0 mCi/μAh for a 4-h radiochemistry) due to decay losses. A radiochemical process used to prepare no-carrier-added (NCA) 101mRh is also explained, with emphasis on its effect on 101mRh yields.
|Original language||English (US)|
|Number of pages||6|
|Journal||The International Journal Of Applied Radiation And Isotopes|
|State||Published - Aug 1984|
ASJC Scopus subject areas
- Nuclear Energy and Engineering
- Radiology Nuclear Medicine and imaging