Cyclooxygenase in biology and disease

Raymond N. DuBois, Steven B. Abramson, Leslie Crofford, Rajnish A. Gupta, Lee S. Simon, Leo B.A. Van De Putte, Peter E. Lipsky

Research output: Contribution to journalArticle

2081 Scopus citations

Abstract

Cyclooxygenase (COX), the key enzyme required for the conversion of arachidonic acid to prostaglandins was first identified over 20 years ago. Drugs, like aspirin, that inhibit cyclooxygenase activity available to the public for about 100 years. In the past decade, however, more progress has been made in understanding the role of cyclooxygenase enzymes in biology and disease than at any other time in history. Two cyclooxygenase isoforms have been identified and are referred to as COX-1 and COX-2. Under many circumstances the COX-1 enzymes is produced constitutively (i.e., gastric mucosa) whereas COX-2 is inducible (i.e., sites of inflammation). Here, we summarize the current understanding of the role of cylooxygenase-1 and -2 in different physiological situations and disease processes ranging from inflammation to cancer. We have attempted to include all of the most relevant material in the field, but due to the rapid progress in this area of research we apologize that certain recent findings may have left out.

Original languageEnglish (US)
Pages (from-to)1063-1073
Number of pages11
JournalFASEB Journal
Volume12
Issue number12
DOIs
StatePublished - 1998

Keywords

  • Frostaglandins
  • Inflammation

ASJC Scopus subject areas

  • Biotechnology
  • Biochemistry
  • Molecular Biology
  • Genetics

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    DuBois, R. N., Abramson, S. B., Crofford, L., Gupta, R. A., Simon, L. S., Van De Putte, L. B. A., & Lipsky, P. E. (1998). Cyclooxygenase in biology and disease. FASEB Journal, 12(12), 1063-1073. https://doi.org/10.1096/fasebj.12.12.1063