Cyclo-oxygenase-2-derived prostacyclin mediates embryo implantation in the mouse via PPARδ

Hyunjung Lim, Rajnish A. Gupta, Wen Ge Ma, Bibhash C. Paria, David E. Moller, Jason D. Morrow, Raymond N. DuBois, James M. Trzaskos, Sudhansu K. Dey

Research output: Contribution to journalArticle

484 Citations (Scopus)

Abstract

We have demonstrated previously that cyclo-oxygenase-2 (COX2), the rate- limiting enzyme in the biosynthesis of prostaglandins (PGs), is essential for blastocyst implantation and decidualization. However, the candidate PG(s) that participates in these processes and the mechanism of its action remain undefined. Using COX2-deficient mice and multiple approaches, we demonstrate herein that COX2-derived prostacyclin (PGI2) is the primary PG that is essential for implantation and decidualization. Several lines of evidence suggest that the effects of PGI2 are mediated by its activation of the nuclear hormone receptor PPARδ, demonstrating the first reported biologic function of this receptor signaling pathway.

Original languageEnglish (US)
Pages (from-to)1561-1574
Number of pages14
JournalGenes and Development
Volume13
Issue number12
StatePublished - Jun 15 1999
Externally publishedYes

Fingerprint

Peroxisome Proliferator-Activated Receptors
Epoprostenol
Prostaglandin-Endoperoxide Synthases
Prostaglandins
Cytoplasmic and Nuclear Receptors
Enzymes

Keywords

  • COX2
  • Implantation
  • Mouse
  • PPARδ
  • Prostaglandins

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology

Cite this

Lim, H., Gupta, R. A., Ma, W. G., Paria, B. C., Moller, D. E., Morrow, J. D., ... Dey, S. K. (1999). Cyclo-oxygenase-2-derived prostacyclin mediates embryo implantation in the mouse via PPARδ. Genes and Development, 13(12), 1561-1574.

Cyclo-oxygenase-2-derived prostacyclin mediates embryo implantation in the mouse via PPARδ. / Lim, Hyunjung; Gupta, Rajnish A.; Ma, Wen Ge; Paria, Bibhash C.; Moller, David E.; Morrow, Jason D.; DuBois, Raymond N.; Trzaskos, James M.; Dey, Sudhansu K.

In: Genes and Development, Vol. 13, No. 12, 15.06.1999, p. 1561-1574.

Research output: Contribution to journalArticle

Lim, H, Gupta, RA, Ma, WG, Paria, BC, Moller, DE, Morrow, JD, DuBois, RN, Trzaskos, JM & Dey, SK 1999, 'Cyclo-oxygenase-2-derived prostacyclin mediates embryo implantation in the mouse via PPARδ', Genes and Development, vol. 13, no. 12, pp. 1561-1574.
Lim H, Gupta RA, Ma WG, Paria BC, Moller DE, Morrow JD et al. Cyclo-oxygenase-2-derived prostacyclin mediates embryo implantation in the mouse via PPARδ. Genes and Development. 1999 Jun 15;13(12):1561-1574.
Lim, Hyunjung ; Gupta, Rajnish A. ; Ma, Wen Ge ; Paria, Bibhash C. ; Moller, David E. ; Morrow, Jason D. ; DuBois, Raymond N. ; Trzaskos, James M. ; Dey, Sudhansu K. / Cyclo-oxygenase-2-derived prostacyclin mediates embryo implantation in the mouse via PPARδ. In: Genes and Development. 1999 ; Vol. 13, No. 12. pp. 1561-1574.
@article{794f40a381254c149d0ffce9d9585290,
title = "Cyclo-oxygenase-2-derived prostacyclin mediates embryo implantation in the mouse via PPARδ",
abstract = "We have demonstrated previously that cyclo-oxygenase-2 (COX2), the rate- limiting enzyme in the biosynthesis of prostaglandins (PGs), is essential for blastocyst implantation and decidualization. However, the candidate PG(s) that participates in these processes and the mechanism of its action remain undefined. Using COX2-deficient mice and multiple approaches, we demonstrate herein that COX2-derived prostacyclin (PGI2) is the primary PG that is essential for implantation and decidualization. Several lines of evidence suggest that the effects of PGI2 are mediated by its activation of the nuclear hormone receptor PPARδ, demonstrating the first reported biologic function of this receptor signaling pathway.",
keywords = "COX2, Implantation, Mouse, PPARδ, Prostaglandins",
author = "Hyunjung Lim and Gupta, {Rajnish A.} and Ma, {Wen Ge} and Paria, {Bibhash C.} and Moller, {David E.} and Morrow, {Jason D.} and DuBois, {Raymond N.} and Trzaskos, {James M.} and Dey, {Sudhansu K.}",
year = "1999",
month = "6",
day = "15",
language = "English (US)",
volume = "13",
pages = "1561--1574",
journal = "Genes and Development",
issn = "0890-9369",
publisher = "Cold Spring Harbor Laboratory Press",
number = "12",

}

TY - JOUR

T1 - Cyclo-oxygenase-2-derived prostacyclin mediates embryo implantation in the mouse via PPARδ

AU - Lim, Hyunjung

AU - Gupta, Rajnish A.

AU - Ma, Wen Ge

AU - Paria, Bibhash C.

AU - Moller, David E.

AU - Morrow, Jason D.

AU - DuBois, Raymond N.

AU - Trzaskos, James M.

AU - Dey, Sudhansu K.

PY - 1999/6/15

Y1 - 1999/6/15

N2 - We have demonstrated previously that cyclo-oxygenase-2 (COX2), the rate- limiting enzyme in the biosynthesis of prostaglandins (PGs), is essential for blastocyst implantation and decidualization. However, the candidate PG(s) that participates in these processes and the mechanism of its action remain undefined. Using COX2-deficient mice and multiple approaches, we demonstrate herein that COX2-derived prostacyclin (PGI2) is the primary PG that is essential for implantation and decidualization. Several lines of evidence suggest that the effects of PGI2 are mediated by its activation of the nuclear hormone receptor PPARδ, demonstrating the first reported biologic function of this receptor signaling pathway.

AB - We have demonstrated previously that cyclo-oxygenase-2 (COX2), the rate- limiting enzyme in the biosynthesis of prostaglandins (PGs), is essential for blastocyst implantation and decidualization. However, the candidate PG(s) that participates in these processes and the mechanism of its action remain undefined. Using COX2-deficient mice and multiple approaches, we demonstrate herein that COX2-derived prostacyclin (PGI2) is the primary PG that is essential for implantation and decidualization. Several lines of evidence suggest that the effects of PGI2 are mediated by its activation of the nuclear hormone receptor PPARδ, demonstrating the first reported biologic function of this receptor signaling pathway.

KW - COX2

KW - Implantation

KW - Mouse

KW - PPARδ

KW - Prostaglandins

UR - http://www.scopus.com/inward/record.url?scp=0033564698&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033564698&partnerID=8YFLogxK

M3 - Article

C2 - 10385625

AN - SCOPUS:0033564698

VL - 13

SP - 1561

EP - 1574

JO - Genes and Development

JF - Genes and Development

SN - 0890-9369

IS - 12

ER -