Cyclo-oxygenase-2-derived prostacyclin mediates embryo implantation in the mouse via PPARδ

Hyunjung Lim, Rajnish A. Gupta, Wen Ge Ma, Bibhash C. Paria, David E. Moller, Jason D. Morrow, Raymond N. DuBois, James M. Trzaskos, Sudhansu K. Dey

Research output: Contribution to journalArticle

488 Scopus citations

Abstract

We have demonstrated previously that cyclo-oxygenase-2 (COX2), the rate- limiting enzyme in the biosynthesis of prostaglandins (PGs), is essential for blastocyst implantation and decidualization. However, the candidate PG(s) that participates in these processes and the mechanism of its action remain undefined. Using COX2-deficient mice and multiple approaches, we demonstrate herein that COX2-derived prostacyclin (PGI2) is the primary PG that is essential for implantation and decidualization. Several lines of evidence suggest that the effects of PGI2 are mediated by its activation of the nuclear hormone receptor PPARδ, demonstrating the first reported biologic function of this receptor signaling pathway.

Original languageEnglish (US)
Pages (from-to)1561-1574
Number of pages14
JournalGenes and Development
Volume13
Issue number12
DOIs
StatePublished - Jun 15 1999

    Fingerprint

Keywords

  • COX2
  • Implantation
  • Mouse
  • PPARδ
  • Prostaglandins

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology

Cite this

Lim, H., Gupta, R. A., Ma, W. G., Paria, B. C., Moller, D. E., Morrow, J. D., DuBois, R. N., Trzaskos, J. M., & Dey, S. K. (1999). Cyclo-oxygenase-2-derived prostacyclin mediates embryo implantation in the mouse via PPARδ. Genes and Development, 13(12), 1561-1574. https://doi.org/10.1101/gad.13.12.1561