Cyclo-oxygenase-2-derived prostacyclin mediates embryo implantation in the mouse via PPARδ

Hyunjung Lim, Rajnish A. Gupta, Wen Ge Ma, Bibhash C. Paria, David E. Moller, Jason D. Morrow, Raymond N. DuBois, James M. Trzaskos, Sudhansu K. Dey

Research output: Contribution to journalArticlepeer-review

523 Scopus citations

Abstract

We have demonstrated previously that cyclo-oxygenase-2 (COX2), the rate- limiting enzyme in the biosynthesis of prostaglandins (PGs), is essential for blastocyst implantation and decidualization. However, the candidate PG(s) that participates in these processes and the mechanism of its action remain undefined. Using COX2-deficient mice and multiple approaches, we demonstrate herein that COX2-derived prostacyclin (PGI2) is the primary PG that is essential for implantation and decidualization. Several lines of evidence suggest that the effects of PGI2 are mediated by its activation of the nuclear hormone receptor PPARδ, demonstrating the first reported biologic function of this receptor signaling pathway.

Original languageEnglish (US)
Pages (from-to)1561-1574
Number of pages14
JournalGenes and Development
Volume13
Issue number12
DOIs
StatePublished - Jun 15 1999
Externally publishedYes

Keywords

  • COX2
  • Implantation
  • Mouse
  • PPARδ
  • Prostaglandins

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology

Fingerprint

Dive into the research topics of 'Cyclo-oxygenase-2-derived prostacyclin mediates embryo implantation in the mouse via PPARδ'. Together they form a unique fingerprint.

Cite this