Cyclo-oxygenase-2-derived prostacyclin mediates embryo implantation in the mouse via PPARδ

Hyunjung Lim, Rajnish A. Gupta, Wen Ge Ma, Bibhash C. Paria, David E. Moller, Jason D. Morrow, Raymond N. DuBois, James M. Trzaskos, Sudhansu K. Dey

    Research output: Contribution to journalArticlepeer-review

    507 Scopus citations

    Abstract

    We have demonstrated previously that cyclo-oxygenase-2 (COX2), the rate- limiting enzyme in the biosynthesis of prostaglandins (PGs), is essential for blastocyst implantation and decidualization. However, the candidate PG(s) that participates in these processes and the mechanism of its action remain undefined. Using COX2-deficient mice and multiple approaches, we demonstrate herein that COX2-derived prostacyclin (PGI2) is the primary PG that is essential for implantation and decidualization. Several lines of evidence suggest that the effects of PGI2 are mediated by its activation of the nuclear hormone receptor PPARδ, demonstrating the first reported biologic function of this receptor signaling pathway.

    Original languageEnglish (US)
    Pages (from-to)1561-1574
    Number of pages14
    JournalGenes and Development
    Volume13
    Issue number12
    DOIs
    StatePublished - Jun 15 1999

    Keywords

    • COX2
    • Implantation
    • Mouse
    • PPARδ
    • Prostaglandins

    ASJC Scopus subject areas

    • Genetics
    • Developmental Biology

    Fingerprint

    Dive into the research topics of 'Cyclo-oxygenase-2-derived prostacyclin mediates embryo implantation in the mouse via PPARδ'. Together they form a unique fingerprint.

    Cite this