Cuboid Vesicles Formed by Frame-Guided Assembly on DNA Origami Scaffolds

Yuanchen Dong; Yuhe Renee Yang; Yiyang Zhang; Dianming Wang; Xixi Wei; Saswata Banerjee; Yan Liu; Zhongqiang Yang; Hao Yan; Dongsheng Liu

doi:10.1002/anie.201610133

Cuboid Vesicles Formed by Frame-Guided Assembly on DNA Origami Scaffolds

Yuanchen Dong, Yuhe Renee Yang, Yiyang Zhang, Dianming Wang, Xixi Wei, Saswata Banerjee, Yan Liu, Zhongqiang Yang, Hao Yan, Dongsheng Liu

Research output: Contribution to journal › Article › peer-review

80 Scopus citations

Abstract

We describe the use of a frame-guided assembly (FGA) strategy to construct cuboid and dumbbell-shaped hetero-vesicles on DNA origami nanostructure scaffolds. These are achieved by varying the design of the DNA origami scaffolds that direct the distribution of the leading hydrophobic groups (LHG). By careful selection of LHGs, different types of amphiphiles (both polymer and small-molecule surfactants) were guided to form hetero-vesicles, demonstrating the versatility of the FGA strategy and its potential to construct asymmetric and dynamic hetero-vesicle assemblies with complex DNA nano-scaffolds.

Original language	English (US)
Pages (from-to)	1586-1589
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	56
Issue number	6
DOIs	https://doi.org/10.1002/anie.201610133
State	Published - Feb 2017

Keywords

DNA nanotechnology
amphiphiles
frame-guided assembly
self-assembly

ASJC Scopus subject areas

Catalysis
General Chemistry

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10.1002/anie.201610133

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title = "Cuboid Vesicles Formed by Frame-Guided Assembly on DNA Origami Scaffolds",

abstract = "We describe the use of a frame-guided assembly (FGA) strategy to construct cuboid and dumbbell-shaped hetero-vesicles on DNA origami nanostructure scaffolds. These are achieved by varying the design of the DNA origami scaffolds that direct the distribution of the leading hydrophobic groups (LHG). By careful selection of LHGs, different types of amphiphiles (both polymer and small-molecule surfactants) were guided to form hetero-vesicles, demonstrating the versatility of the FGA strategy and its potential to construct asymmetric and dynamic hetero-vesicle assemblies with complex DNA nano-scaffolds.",

keywords = "DNA nanotechnology, amphiphiles, frame-guided assembly, self-assembly",

author = "Yuanchen Dong and Yang, {Yuhe Renee} and Yiyang Zhang and Dianming Wang and Xixi Wei and Saswata Banerjee and Yan Liu and Zhongqiang Yang and Hao Yan and Dongsheng Liu",

note = "Funding Information: We thank the National Basic Research Program of China (973 program, no. 2013CB932803), the National Natural Science Foundation of China (nos. 91027046 and 21121004), and NSFC-DFG joint project TRR61 for financial support. Publisher Copyright: {\textcopyright} 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim",

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month = feb,

doi = "10.1002/anie.201610133",

language = "English (US)",

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AU - Dong, Yuanchen

AU - Yang, Yuhe Renee

AU - Zhang, Yiyang

AU - Wang, Dianming

AU - Wei, Xixi

AU - Banerjee, Saswata

AU - Liu, Yan

AU - Yang, Zhongqiang

AU - Yan, Hao

AU - Liu, Dongsheng

N1 - Funding Information: We thank the National Basic Research Program of China (973 program, no. 2013CB932803), the National Natural Science Foundation of China (nos. 91027046 and 21121004), and NSFC-DFG joint project TRR61 for financial support. Publisher Copyright: © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim

PY - 2017/2

Y1 - 2017/2

N2 - We describe the use of a frame-guided assembly (FGA) strategy to construct cuboid and dumbbell-shaped hetero-vesicles on DNA origami nanostructure scaffolds. These are achieved by varying the design of the DNA origami scaffolds that direct the distribution of the leading hydrophobic groups (LHG). By careful selection of LHGs, different types of amphiphiles (both polymer and small-molecule surfactants) were guided to form hetero-vesicles, demonstrating the versatility of the FGA strategy and its potential to construct asymmetric and dynamic hetero-vesicle assemblies with complex DNA nano-scaffolds.

AB - We describe the use of a frame-guided assembly (FGA) strategy to construct cuboid and dumbbell-shaped hetero-vesicles on DNA origami nanostructure scaffolds. These are achieved by varying the design of the DNA origami scaffolds that direct the distribution of the leading hydrophobic groups (LHG). By careful selection of LHGs, different types of amphiphiles (both polymer and small-molecule surfactants) were guided to form hetero-vesicles, demonstrating the versatility of the FGA strategy and its potential to construct asymmetric and dynamic hetero-vesicle assemblies with complex DNA nano-scaffolds.

KW - DNA nanotechnology

KW - amphiphiles

KW - frame-guided assembly

KW - self-assembly

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JO - Angewandte Chemie - International Edition

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Cuboid Vesicles Formed by Frame-Guided Assembly on DNA Origami Scaffolds

Abstract

Keywords

ASJC Scopus subject areas

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