Cryptosporidiosis facilitated by murine retroviral infection with LP-BM5

H. Darban, J. Enriquez, C. R. Sterling, M. C. Lopez, G. Chen, Morteza Abbaszadegan, R. R. Watson

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

LP-BM5 murine leukemia virus infection caused alterations in splenic T cell subsets in adult C57BL/6 female mice. Prolonged infection resulted in increased immunosuppression and a concomitant decreased resistance to Cryptosporidium parvum infection. Significant Cryptosporidium colonization of the intestinal villi was seen 10 days after oral challenge in mice infected with murine retrovirus for 3 months but not in non-virally infected controls. Parasite numbers per villus of retrovirally infected mice were 20-fold higher than in controls, which showed only occasional parasites. Feces from most virally infected mice but none from controls contained oocysts. Cryptosporidium infection in mice after 4 and 5 months of retroviral infection was accompanied by severe immunosuppression and parasite levels 50-5000 times higher than in controls. A high level of infection persisted 21 days after Cryptosporidium challenge in virally infected mice, while controls cleared their transient and marginal infection. These results further characterize LP-BM5 infection as a murine model of retrovirally induced acquired immune deficiency.

Original languageEnglish (US)
Pages (from-to)741-745
Number of pages5
JournalJournal of Infectious Diseases
Volume164
Issue number4
StatePublished - Oct 1991
Externally publishedYes

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Cryptosporidiosis
Cryptosporidium
Infection
Parasites
Immunosuppression
Cryptosporidium parvum
Murine Leukemia Viruses
Oocysts
T-Lymphocyte Subsets
Virus Diseases
Retroviridae
Feces

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Immunology

Cite this

Darban, H., Enriquez, J., Sterling, C. R., Lopez, M. C., Chen, G., Abbaszadegan, M., & Watson, R. R. (1991). Cryptosporidiosis facilitated by murine retroviral infection with LP-BM5. Journal of Infectious Diseases, 164(4), 741-745.

Cryptosporidiosis facilitated by murine retroviral infection with LP-BM5. / Darban, H.; Enriquez, J.; Sterling, C. R.; Lopez, M. C.; Chen, G.; Abbaszadegan, Morteza; Watson, R. R.

In: Journal of Infectious Diseases, Vol. 164, No. 4, 10.1991, p. 741-745.

Research output: Contribution to journalArticle

Darban, H, Enriquez, J, Sterling, CR, Lopez, MC, Chen, G, Abbaszadegan, M & Watson, RR 1991, 'Cryptosporidiosis facilitated by murine retroviral infection with LP-BM5', Journal of Infectious Diseases, vol. 164, no. 4, pp. 741-745.
Darban H, Enriquez J, Sterling CR, Lopez MC, Chen G, Abbaszadegan M et al. Cryptosporidiosis facilitated by murine retroviral infection with LP-BM5. Journal of Infectious Diseases. 1991 Oct;164(4):741-745.
Darban, H. ; Enriquez, J. ; Sterling, C. R. ; Lopez, M. C. ; Chen, G. ; Abbaszadegan, Morteza ; Watson, R. R. / Cryptosporidiosis facilitated by murine retroviral infection with LP-BM5. In: Journal of Infectious Diseases. 1991 ; Vol. 164, No. 4. pp. 741-745.
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