Cryptosporidiosis facilitated by murine retroviral infection with LP-BM5

H. Darban, J. Enriquez, C. R. Sterling, M. C. Lopez, G. Chen, M. Abbaszadegan, R. R. Watson

Research output: Contribution to journalArticle

35 Scopus citations

Abstract

LP-BM5 murine leukemia virus infection caused alterations in splenic T cell subsets in adult C57BL/6 female mice. Prolonged infection resulted in increased immunosuppression and a concomitant decreased resistance to Cryptosporidium parvum infection. Significant Cryptosporidium colonization of the intestinal villi was seen 10 days after oral challenge in mice infected with murine retrovirus for 3 months but not in non-virally infected controls. Parasite numbers per villus of retrovirally infected mice were 20-fold higher than in controls, which showed only occasional parasites. Feces from most virally infected mice but none from controls contained oocysts. Cryptosporidium infection in mice after 4 and 5 months of retroviral infection was accompanied by severe immunosuppression and parasite levels 50-5000 times higher than in controls. A high level of infection persisted 21 days after Cryptosporidium challenge in virally infected mice, while controls cleared their transient and marginal infection. These results further characterize LP-BM5 infection as a murine model of retrovirally induced acquired immune deficiency.

Original languageEnglish (US)
Pages (from-to)741-745
Number of pages5
JournalJournal of Infectious Diseases
Volume164
Issue number4
DOIs
StatePublished - Oct 1991
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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    Darban, H., Enriquez, J., Sterling, C. R., Lopez, M. C., Chen, G., Abbaszadegan, M., & Watson, R. R. (1991). Cryptosporidiosis facilitated by murine retroviral infection with LP-BM5. Journal of Infectious Diseases, 164(4), 741-745. https://doi.org/10.1093/infdis/164.4.741