Cross-clade HIV-1 neutralization by an antibody fragment from a lupus phage display library

Sangeeta Karle, Stephanie Planque, Yasuhiro Nishiyama, Hiroaki Taguchi, Yong Xin Zhou, Maria Salas, Douglas Lake, Perumal Thiagarajan, Frank Arnett, Carl V. Hanson, Sudhir Paul

Research output: Contribution to journalArticle

24 Scopus citations

Abstract

A single-chain fragment containing antibody V domains (scFv) isolated from a lupus antibody library displayed the ability to bind gp120 and the conserved gp120 determinant composed of residues 421-436. The scFv neutralized R5 and X4-dependent HIV-1 strains from clades B, C and D. The lupus repertoire may be useful as a source of neutralizing antibodies to HIV.

Original languageEnglish (US)
Pages (from-to)329-331
Number of pages3
JournalAIDS
Volume18
Issue number2
DOIs
StatePublished - Jan 23 2004
Externally publishedYes

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ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

Cite this

Karle, S., Planque, S., Nishiyama, Y., Taguchi, H., Zhou, Y. X., Salas, M., Lake, D., Thiagarajan, P., Arnett, F., Hanson, C. V., & Paul, S. (2004). Cross-clade HIV-1 neutralization by an antibody fragment from a lupus phage display library. AIDS, 18(2), 329-331. https://doi.org/10.1097/00002030-200401230-00026