Cross-clade HIV-1 neutralization by an antibody fragment from a lupus phage display library

Sangeeta Karle; Stephanie Planque; Yasuhiro Nishiyama; Hiroaki Taguchi; Yong Xin Zhou; Maria Salas; Douglas Lake; Perumal Thiagarajan; Frank Arnett; Carl V. Hanson; Sudhir Paul

doi:10.1097/00002030-200401230-00026

Cross-clade HIV-1 neutralization by an antibody fragment from a lupus phage display library

Sangeeta Karle, Stephanie Planque, Yasuhiro Nishiyama, Hiroaki Taguchi, Yong Xin Zhou, Maria Salas, Douglas Lake, Perumal Thiagarajan, Frank Arnett, Carl V. Hanson, Sudhir Paul

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

A single-chain fragment containing antibody V domains (scFv) isolated from a lupus antibody library displayed the ability to bind gp120 and the conserved gp120 determinant composed of residues 421-436. The scFv neutralized R5 and X4-dependent HIV-1 strains from clades B, C and D. The lupus repertoire may be useful as a source of neutralizing antibodies to HIV.

Original language	English (US)
Pages (from-to)	329-331
Number of pages	3
Journal	AIDS
Volume	18
Issue number	2
DOIs	https://doi.org/10.1097/00002030-200401230-00026
State	Published - Jan 23 2004
Externally published	Yes

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Infectious Diseases

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10.1097/00002030-200401230-00026

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abstract = "A single-chain fragment containing antibody V domains (scFv) isolated from a lupus antibody library displayed the ability to bind gp120 and the conserved gp120 determinant composed of residues 421-436. The scFv neutralized R5 and X4-dependent HIV-1 strains from clades B, C and D. The lupus repertoire may be useful as a source of neutralizing antibodies to HIV.",

author = "Sangeeta Karle and Stephanie Planque and Yasuhiro Nishiyama and Hiroaki Taguchi and Zhou, {Yong Xin} and Maria Salas and Douglas Lake and Perumal Thiagarajan and Frank Arnett and Hanson, {Carl V.} and Sudhir Paul",

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T1 - Cross-clade HIV-1 neutralization by an antibody fragment from a lupus phage display library

AU - Karle, Sangeeta

AU - Planque, Stephanie

AU - Nishiyama, Yasuhiro

AU - Taguchi, Hiroaki

AU - Zhou, Yong Xin

AU - Salas, Maria

AU - Lake, Douglas

AU - Thiagarajan, Perumal

AU - Arnett, Frank

AU - Hanson, Carl V.

AU - Paul, Sudhir

PY - 2004/1/23

Y1 - 2004/1/23

N2 - A single-chain fragment containing antibody V domains (scFv) isolated from a lupus antibody library displayed the ability to bind gp120 and the conserved gp120 determinant composed of residues 421-436. The scFv neutralized R5 and X4-dependent HIV-1 strains from clades B, C and D. The lupus repertoire may be useful as a source of neutralizing antibodies to HIV.

AB - A single-chain fragment containing antibody V domains (scFv) isolated from a lupus antibody library displayed the ability to bind gp120 and the conserved gp120 determinant composed of residues 421-436. The scFv neutralized R5 and X4-dependent HIV-1 strains from clades B, C and D. The lupus repertoire may be useful as a source of neutralizing antibodies to HIV.

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JO - AIDS

JF - AIDS

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ER -

Cross-clade HIV-1 neutralization by an antibody fragment from a lupus phage display library

Abstract

ASJC Scopus subject areas

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