Cross-clade HIV-1 neutralization by an antibody fragment from a lupus phage display library

Sangeeta Karle, Stephanie Planque, Yasuhiro Nishiyama, Hiroaki Taguchi, Yong Xin Zhou, Maria Salas, Douglas Lake, Perumal Thiagarajan, Frank Arnett, Carl V. Hanson, Sudhir Paul

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

A single-chain fragment containing antibody V domains (scFv) isolated from a lupus antibody library displayed the ability to bind gp120 and the conserved gp120 determinant composed of residues 421-436. The scFv neutralized R5 and X4-dependent HIV-1 strains from clades B, C and D. The lupus repertoire may be useful as a source of neutralizing antibodies to HIV.

Original languageEnglish (US)
Pages (from-to)329-331
Number of pages3
JournalAIDS
Volume18
Issue number2
DOIs
StatePublished - Jan 23 2004
Externally publishedYes

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Immunoglobulin Fragments
Neutralizing Antibodies
Bacteriophages
Libraries
HIV-1
HIV
Antibodies

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Karle, S., Planque, S., Nishiyama, Y., Taguchi, H., Zhou, Y. X., Salas, M., ... Paul, S. (2004). Cross-clade HIV-1 neutralization by an antibody fragment from a lupus phage display library. AIDS, 18(2), 329-331. https://doi.org/10.1097/00002030-200401230-00026

Cross-clade HIV-1 neutralization by an antibody fragment from a lupus phage display library. / Karle, Sangeeta; Planque, Stephanie; Nishiyama, Yasuhiro; Taguchi, Hiroaki; Zhou, Yong Xin; Salas, Maria; Lake, Douglas; Thiagarajan, Perumal; Arnett, Frank; Hanson, Carl V.; Paul, Sudhir.

In: AIDS, Vol. 18, No. 2, 23.01.2004, p. 329-331.

Research output: Contribution to journalArticle

Karle, S, Planque, S, Nishiyama, Y, Taguchi, H, Zhou, YX, Salas, M, Lake, D, Thiagarajan, P, Arnett, F, Hanson, CV & Paul, S 2004, 'Cross-clade HIV-1 neutralization by an antibody fragment from a lupus phage display library', AIDS, vol. 18, no. 2, pp. 329-331. https://doi.org/10.1097/00002030-200401230-00026
Karle S, Planque S, Nishiyama Y, Taguchi H, Zhou YX, Salas M et al. Cross-clade HIV-1 neutralization by an antibody fragment from a lupus phage display library. AIDS. 2004 Jan 23;18(2):329-331. https://doi.org/10.1097/00002030-200401230-00026
Karle, Sangeeta ; Planque, Stephanie ; Nishiyama, Yasuhiro ; Taguchi, Hiroaki ; Zhou, Yong Xin ; Salas, Maria ; Lake, Douglas ; Thiagarajan, Perumal ; Arnett, Frank ; Hanson, Carl V. ; Paul, Sudhir. / Cross-clade HIV-1 neutralization by an antibody fragment from a lupus phage display library. In: AIDS. 2004 ; Vol. 18, No. 2. pp. 329-331.
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